Neural, Computational, and Neuromechanical Approaches to Motor Control

运动控制的神经、计算和神经机械方法

• 批准号: 10630962
• 负责人: MELINA E HALE
• 金额: $ 35.96万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630962
• 关键词: Neuromechanics; motor control; neural

ABSTRACT Research and training on motor control at UChicago have a unique history of combining neurobiology and neuromechanics research with computational approaches. In the past few years, the University has significantly expanded its neuroscience community with the establishment of the new Neuroscience Institute. The significant investments have created exciting new opportunities for research and training in the area of motor control and movement and related disorders, especially in addressing questions by integrating experimental and computational approaches. Our training program will take advantage of the existing breadth and depth of motor control and movement research on campus. We have 15 Trainers whose research is focused on motor control and movement, covering a broad range from genetic, molecular and cellular studies to circuit, systems, biomechanics and computational approaches. Our research interests have a broad anatomic scope, from neuromuscular junction and spinal cord to cerebellum, basal ganglia and cerebral cortex. We employ a broad range of model organisms including invertebrates, insects, zebrafish and mice to non-human primates and human subjects. In evaluating candidates for the Training Program, a criterion will be their demonstrated interest in bridging experimental and computational work as an element of their dissertations. Trainees will complete the following Program Elements. 1. The “Experimental Design in Motor Control Research” course. 2. One or two rotations that broaden exposure to approaches. 3. Annual problem-solving workshop. 4. Journal club that emphasizes statistical methods. With the activities, we will bring together faculty and students whose work is mainly experimental and those whose work is computational. We will explore as a community how fundamental questions in motor control can be addressed at a range of levels of approach. In addition to the trainees supported by the T32, we will add Associate Members so that any trainee who is working on motor control research or is interested in motor control research could participate in T32 sponsored activities. All trainees will gain key skills in statistics methods. Writing and presentation skills will be emphasized throughout the training. Faculty in our Training Program have primary appointments in five departments (Neurology, Neurobiology, Organismal Biology and Anatomy, Molecular Genetics and Cell Biology, Anesthesia and Critical Care), and appointments in one or more than one of the five participating Graduate Programs (Neurobiology; Computational Neuroscience; Genetics, Genomics and Systems Biology; Integrative Biology; Medical Scientist Training Program). We propose to support 6 predoctoral trainees (starting with 3 slots in year 1). Students will be supported for 2 years during years 3 and 4 of their graduate training. We will appoint 3 new trainees every year.

摘要 芝加哥大学运动控制的研究和培训有着独特的历史，将神经生物学和 神经力学研究与计算方法。在过去的几年里，大学 随着新的神经科学研究所的建立，它大大扩大了神经科学界。 这些重大投资为以下领域的研究和培训创造了令人兴奋的新机会： 运动控制和运动及相关疾病，特别是在解决问题的整合 实验和计算方法。 我们的训练计划将利用现有的广度和深度的运动控制和运动 校园里的研究我们有15名教练，他们的研究重点是运动控制和运动， 涵盖范围广泛，从遗传，分子和细胞研究到电路，系统，生物力学和 计算方法。我们的研究兴趣有广泛的解剖学范围，从神经肌肉接头 以及脊髓到小脑、基底神经节和大脑皮层。我们采用广泛的模型 在一些实施方案中，本发明涉及将包括无脊椎动物、昆虫、斑马鱼和小鼠在内的生物体用于非人灵长类动物和人类受试者。 在评估培训计划的候选人时，一个标准是他们表现出的对桥接的兴趣。 实验和计算工作作为他们论文的一个元素。学员将完成以下内容 程序元素。1.“电机控制研究实验设计”课程。2.一次或两次旋转 这扩大了对各种方法的接触。3.年度解决问题研讨会。4.日记俱乐部强调 统计方法通过这些活动，我们将汇集教师和学生，他们的工作主要是 实验性的和计算性的我们将探索作为一个社区， 运动控制中的问题可以在一系列的方法层次上解决。除了学员之外 在T32的支持下，我们将增加准会员，以便任何从事电机控制的学员 研究或有兴趣在运动控制研究可以参加T32赞助的活动。所有学员将 掌握统计方法的关键技能。写作和演讲技巧将在整个培训中得到强调。 我们培训计划的教师主要负责五个部门（神经病学、神经生物学， 有机体生物学和解剖学，分子遗传学和细胞生物学，麻醉和重症监护），以及 在五个参与研究生课程（神经生物学; 计算神经科学;遗传学、基因组学和系统生物学;综合生物学;医学科学家 培训计划）。 我们建议支持6名博士预科生（从第1年的3个名额开始）。学生将得到支持， 在他们的研究生培训的第3年和第4年期间2年。我们将每年任命3名新学员。