General Motor Control Mechanisms and Disease Training Program

项目总结/摘要 有效地启动、执行和终止运动的能力对于生存至关重要，但在一个 一系列使人衰弱的疾病。神经系统是如何对运动进行编码的， 机器受到疾病的损害仍然知之甚少。神经科学的主要使命 社区是填补我们知识的这些空白，并将这些新信息转化为更好的临床 实践为了推进这一多代人的努力，至关重要的是，早期的职业科学家是很好的- 受到了培训他们需要牢牢掌握我们知道什么，不知道什么，在分子， 细胞和系统水平，并致力于严格的，定量的和道德的研究。有了这些目标 在头脑中，一组30名世界领先的基础，临床和转化运动控制科学家来到 在D博士的领导下James Surmeier将为产前和产后提供培训计划， 博士科学家致力于运动控制研究在西北大学（NU）。的目标 NU一般运动控制机制和疾病培训计划（GMCMD-TP）是：1）教育 在分子，细胞和神经科学的基础，转化和临床运动系统神经科学的学员， 系统水平; 2）为学员提供必要的概念，技术和定量技能， 解决重大问题，挑战教条，做出有影响力的研究发现; 3）鼓励 学员考虑其研究的疾病相关性及其转化潜力; 4）灌输 学员对严谨，道德和负责任的研究的深刻承诺; 5）提高学员的技能， 交流他们的研究; 6）给学员机会，以推进他们的职业目标，使我们 支持电机控制领域的下一代领导者。新加坡国立大学博士预科生 跨部门神经科学（NUIN）计划和生物医学神经工程轨道 工程计划，并在计划教师的实验室博士后实习生有资格获得 GMCMD-TP。GMCMD-TP包括：1）涵盖运动系统各个方面的核心课程， 题为“运动的神经控制”; 2）每月由导师举办关于运动控制的研讨会 研究计划; 3）统计培训和咨询; 4）年度务虚会， NU运动控制研究社区聚集在一起交流和讨论他们的研究; 5）a 基础科学家和临床医生的运动障碍杂志俱乐部; 6）跟踪机会 运动障碍临床医生; 7）几个年度研究中心日，每个都专注于一个特定的运动 控制疾病。此外，GMCMD-TP学员利用个人发展计划和NU专业 发展计划，以进一步促进职业发展。每年多达4个博士前和3个博士后 博士生将有资格获得1-2年的直接支助。GMCMD-TP实验室中的受训人员， 获得直接支持的人也会得到同样的培训。

PROJECT SUMMARY/ABSTRACT The ability to initiate, execute, and terminate movement effectively is critical for survival but is impaired in a range of debilitating diseases. Precisely how the nervous system encodes movement and how this neural machinery is compromised by disease remain poorly understood. A primary mission of the neuroscience community is to fill these gaps in our knowledge and translate this new information into better clinical practice. To carry this multi-generational effort forward, it is critical that early career scientists are well- trained. They need a firm grasp of what we know and don't know, experimental skills at the molecular, cellular, and systems levels, and dedication to rigorous, quantitative, and ethical research. With these goals in mind, a group of 30 world-leading basic, clinical and translational motor control scientists have come together under the directorship of Dr. D. James Surmeier to deliver a training program for pre- and post- doctoral scientists committed to motor control research at Northwestern University (NU). The goals of the NU General Motor Control Mechanisms and Disease Training Program (GMCMD-TP) are: 1) to educate trainees in basic, translational, and clinical motor systems neuroscience at the molecular, cellular, and systems levels; 2) to provide trainees with the conceptual, technical, and quantitative skillsets necessary to address major questions, challenge dogma and make impactful research discoveries; 3) to encourage trainees to consider the disease relevance of their research and its translational potential; 4) to instill in trainees a deep commitment to rigorous, ethical, and responsible research; 5) to enhance trainees' skills in communicating their research; 6) to give trainees opportunities to advance their career goals so that we support the next generation of leaders in the field of motor control. Pre-doctoral trainees in the NU Interdepartmental Neuroscience (NUIN) program and the Neural Engineering track of the Biomedical Engineering program, and post-doctoral trainees in the laboratories of program faculty are eligible for the GMCMD-TP. The GMCMD-TP consists of: 1) a core course covering each aspect of the motor system, entitled “The Neural Control of Movement”; 2) monthly seminars by preceptors on their motor control research programs; 3) training and consultation in statistics; 4) an annual retreat where all members of the NU motor control research community come together to communicate and discuss their research; 5) a movement disorders journal club for basic scientists and clinicians; 6) opportunities for shadowing movement disorder clinicians; 7) several annual research center days, each focused on a specific motor control disease. In addition, GMCMD-TP trainees utilize Individual Development Plans and NU professional development programs to further promote career advancement. Each year up to 4 pre-doctoral and 3 post- doctoral trainees will be eligible for direct support for 1-2 years. Trainees in GMCMD-TP labs who do not receive direct support are offered the same training.