Visualsonics Vevo 3100 Ultrasound Imaging

摘要 啮齿动物模型，包括基因工程动物、手术模型和自然发生的 疾病模型，仍然是临床前研究的基石，并被常规用于研究 人类疾病的机制和发病机制，并开发新的治疗方法。高分辨率超声 成像是一种基本的表型工具，能够研究内部动物解剖学和生理学非 在动物的整个生命周期内，在疾病发病机制期间，以及在临床前试验之前或之后 治疗。此SIG应用程序申请资金购买Visualsonics Vevo3100超声成像 系统。这一新的成像系统将对生理表型鉴定核心的操作至关重要， 它在为NIH资助的调查人员提供超声波成像方面有近20年的经验 穿过密歇根大学校园。新款Vevo3100将取代老化的Vevo 2100 达到支持寿命结束时，通常需要昂贵的维修费用。Vevo3100的利用率非常高 频率线性阵列MX系列换能器，提供最高分辨率的2D和3D成像 提供动物心脏的结构和功能，并允许对血液进行定量的功能成像 小到小鼠胚胎，大到大鼠和兔子的动物体内的血管和肿瘤体积。EKG和 呼吸门控和EKV软件提供无与伦比的电影环路图像重建 以每秒10,000帧的速度循环，并实现了一种新型的4D成像模式(3D+时间)来捕获3D 心脏在心动周期中的成像，分辨率接近MRI水平，但时间和 成本。此外，VevoVasc成像分析和高分辨率彩色多普勒成像提供了 能够分析血管疾病的后果，包括动脉瘤、动脉硬化和 血栓形成的生理效应。重要的是，Vevo3100将被整合到一个强大的、完全 拥有专业超声技术人员的功能动物表型核心，高效的补充机制， 常备动物规程、程序空间和实验室动物支持，以方便接触新手或专家 整个大学的用户。核心还使用户能够访问心血管疾病的手术模型， 遥测记录、血压、药物输送和其他提供管道的表型模式 用于从疾病模型到实验结果的临床前研究。例如，当与 生理表型核心VevoVasc提供的血压遥测服务允许实时 血管壁力学的无创性分析。总体而言，Vevo3100将允许生理学 表型鉴定核心为NIH资助的用户提供最新的功能超声成像模式， 通过更换老化的报废设备，将允许核心继续提供超声波服务 用户进入下一个十年。

Abstract Rodent animal models, including genetically engineered animals, surgical models, and naturally occurring disease models, remain the cornerstone of preclinical research, and are routinely used to study the mechanisms and pathogenesis of human disease and develop new therapies. High resolution ultrasound imaging is an essential phenotyping tool to be able to study internal animal anatomy and physiology non- invasively across the animal’s lifespan, during disease pathogenesis, and before or after preclinical testing of treatments. This SIG application requests funds to purchase a Visualsonics Vevo3100 Ultrasound Imaging System. This new imaging system will be essential to the operations of the Physiology Phenotyping Core, which has almost two decades of experience in providing ultrasound imaging to NIH funded investigators across the University of Michigan Campus. The new Vevo3100 will replace an aging Vevo 2100 that has reached its end of supported lifespan and routinely requires costly repairs. The Vevo3100 utilizes very high frequency linear array MX-series transducers that provide the highest resolution 2D and 3D imaging of small animal heart structure and function available, and also allow for quantitative, functional imaging of blood vessels and tumor volumes in animals as small as mouse embryos and up to large rats and rabbits. EKG and respiration gating and EKV Software provide unparalleled cine loop image reconstruction during the cardiac cycle at up to 10,000 frames per second, and enables a novel 4D Imaging Mode (3D + time) to capture 3D imaging of the heart during the cardiac cycle at near MRI levels of resolution but at a fraction of the time and cost. In addition, the VevoVasc imaging analysis and high-resolution color Doppler imaging provides a capability of analyzing consequences of vascular disease including aneurysms, atherosclerosis and the physiological effects of thrombosis. Importantly, the Vevo3100 will be incorporated into a robust, fully functional animal phenotyping core with expert ultrasound technical staff, an efficient recharge mechanism, standing animal protocols, procedural space, and laboratory animal support to ease access to novice or expert users across the university. The core also provides users access to surgical models of cardiovascular disease, telemetry recording, blood pressure, drug delivery and other phenotyping modalities which provide a pipeline for preclinical studies from disease models to experimental outcomes. For example, when combined with the blood pressure telemetry services available in the Physiology Phenotyping Core, VevoVasc allows for real-time non-invasive analysis of vascular wall mechanics. Overall, the Vevo3100 will allow the Physiology Phenotyping Core to provide new state of the art modes of functional ultrasound imaging to NIH funded users, and by replacing aging end-of-life equipment will allow the core to continue to provide ultrasound services to users into the next decade.