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项目摘要/摘要 新冠肺炎大流行严重影响整个亚利桑那州，但影响到沿线社区 与墨西哥的边界不成比例。这条边境沿线的大多数拉丁裔和美国印第安人社区 更高的感染率和更少的检测和疫苗接种机会。这项拟议的补编旨在增加 这些服务不足的跨国社区获得检测和相关服务的机会。我们的扩展 当前的社区驱动和文化契合的项目将促进对护理障碍和 在边境地区增加检测和疫苗接种的有效战略。此应用程序扩展了工作 亚利桑那州立大学健康差距U54中心补助金(RFA-MD-17-005；5U54MD002316)及其RADx-UP补充 (3U54MD002316-14S1)通过减少新冠肺炎诊断、疫苗接种、教育、总结方面的差异 服务和保健，目标是改善弱势和服务不足社区的健康。 这一紧急竞争性修订的目标与当前U54奖项的目标密切匹配并得到加强 和它的RADX-UP补充物。对亚洲区-墨西哥边境沿线人口的关注将增加现有的 关于不同跨国社区的资产和脆弱性的知识不成比例地受到 大流行。该方法支持当地社区，以数据为驱动，并创建基础设施 以社区为导向提供护理的能力。遵循基于社区的参与性研究(CBPR) 定向，修订后的补编扩大了我们现有的R.A.P.I.D.计划，改善了访问和 减少在服务不足和脆弱人群中对新冠肺炎检测和疫苗接种的犹豫 边境地区。平等健康基金会(EHF)将继续作为社区的主要合作伙伴 拟议修订的补编和亚利桑那州立大学生物设计临床测试实验室(ABCTL)将提供和 分析唾液聚合酶链式反应(PCR)检测SARS-CoV-2。当地合作伙伴 由流行性出血热在对抗新冠肺炎的共同体倡议下协调将实施疫苗接种 程序。在两年内，修订后的补充方案的目标是增加7000名生活在社区的成员 并在亚利桑那州-墨西哥边境工作。来自边境社区的CDCC调查将被添加到 我们正在进行的纵向研究正在进行，以评估干预的影响，并通过比较 随机选择的参与者(N=200)和匹配的对照组(N=200)随机选择自 常规测试地点。我们还将在接受测试的患者中进行持续的新冠肺炎变异序列验证 并在出现重大变异时通知适当的卫生当局。跨学科团队拥有 基础设施、能力和社区合作伙伴关系到位，以有效地实施项目和 效率很高。亚利桑那州立大学现有的由NIMHD资助的U54中心，由其社区和科学咨询委员会指导 并与政府机构、部落政府、社区组织和学术界合作 亚利桑那州立大学内部各单位已做好充分准备，可承担拟议的订正补编。

Project Summary/Abstract The COVID-19 pandemic significantly affects the entire State of Arizona but impacts communities along the border with Mexico disproportionally. Majority Latinx and American Indian communities along this border have higher infection rates and less access to testing and vaccination. This proposed supplement aims to increase access to testing and related services for these underserved transnational communities. The expansion of our current community-driven and culturally congruent project will advance knowledge about barriers to care and effective strategies to increase testing and vaccination in the border region. This application extends the work of ASU’s health disparities U54 center grant (RFA-MD-17-005; 5U54MD002316) and its RADx-UP supplement (3U54MD002316-14S1) by reducing disparities in COVID-19 diagnostics, vaccination, education, wraparound services and health care, with the goal of improving the health of vulnerable and underserved communities. The aims of this emergency competitive revision closely match and enhance the aims of the current U54 award and its RADx-UP supplement. The focus on populations along the AZ-Mexico border will add to existing knowledge about assets and vulnerabilities of diverse transnational communities disproportionally affected by the pandemic. The approach empowers local communities, is data driven, and creates the infrastructure capacity for community-driven delivery of care. Following a Community Based Participatory Research (CBPR) orientation, the revised supplement expands our existing R.A.P.I.D. program by improving access and decreasing hesitancy to COVID-19 testing and vaccination among underserved and vulnerable populations in the border region. Equality Health Foundation (EHF) will continue to serve as the lead community partner for the proposed revised supplement and the ASU Biodesign Clinical Testing Laboratory (ABCTL) will provide and analyze the saliva-based polymerase chain reaction (PCR) testing for SARS-CoV-2. Local partners coordinated by EHF under the One Community Initiative against COVID-19 will implement the vaccination program. Over two years, the revised supplement aims to reach 7,000 additional community members living and working along the AZ-Mexico border. CDCC surveys from border communities will be added to the ongoing longitudinal study we are conducting to assess the intervention’s impact and also by comparing randomly selected participants (N=200) with a matched comparison group (N=200) randomly selected from regular testing sites. We will also conduct ongoing COVID-19 variants sequence validation among those tested and inform appropriate health authorities if significant variants emerge. The transdisciplinary team has the infrastructure, capacity, and community partnerships in place to implement the project effectively and efficiently. ASU’s existing NIMHD-funded U54 center, guided by its Community and Scientific Advisory Board and in collaboration with government agencies, tribal governments, community organizations, and academic units within ASU, is well equipped to undertake the proposed revised supplement.