Cancer Prevention and Control Research Program

项目总结/摘要 Markey癌症中心（MCC）的癌症预防和控制（CP）研究项目高度联合 人口研究和社区癌症控制领域的互补优势 研究的总体目标是减少肯塔基州的癌症差异，重点是该州的 阿巴拉契亚和农村人口。肯塔基州的癌症发病率和死亡率最高 在美国的50个国家中。令人担忧的是，阿巴拉契亚肯塔基州的癌症发病率和死亡率 远高于该州非阿巴拉契亚地区的比率。这些高企的利率是由各种 潜在因素包括社会经济地位低，教育程度低，高危行为， 文化障碍和环境暴露。CP计划的优势包括重点研究 为了揭示环境暴露在肯塔基州高癌症发病率中的作用， 针对独特文化障碍的干预计划，以及戒烟政策的制定 举措CP计划成员也是开发基于人口的方法的国家领导人， 促进跨方案癌症研究的措施。CP计划结合了这些优势， 解决3个专题领域：确定社会、文化、行为、遗传和环境因素， 导致癌症发病率和死亡率升高的因素（主题1）;设计、测试、实施和 评估针对已确定的风险因素（障碍）和减少癌症负担的干预策略 （主题2）;以及制订以人口为基础的方法和措施， 癌症研究旨在更精确地确定治疗模式和生物标志物的分布， 人口（专题3）。最近，CP项目招募了2名国家癌症研究所资助的癌症患者， 分子流行病学家建立其独特的研究资源。目前由28名成员组成的CP团队 来自肯塔基州大学的5个学院和12个系，从而促进了活跃的跨学科 翻译研究CP生产力反映在每年超过1000万美元的外部癌症相关资金总额中。 970万美元（每年直接费用670万美元），本资助期内共出版了245部出版物，其中30部（12%） 其中83个（34%）是方案间的，162个（66%）是机构间的。CP研究 包括癌症控制连续体的所有环节：预防、早期发现、治疗和 生存。CP研究涉及许多癌症部位，包括那些不成比例地导致癌症的部位。 肯塔基州的高癌症负担（即肺癌、结肠癌、乳腺癌和宫颈癌）。因此，CP计划是不可或缺的 实现千年挑战委员会降低英联邦癌症发病率和死亡率的总体使命。

PROJECT SUMMARY/ABSTRACT Markey Cancer Center's (MCC) Cancer Prevention and Control (CP) Research Program unites highly complementary strengths in the areas of population-based research and community-based cancer control research with the overarching goal of reducing cancer disparities in Kentucky with an emphasis on the state's Appalachian and rural populations. Kentucky has the highest overall cancer incidence and mortality rates among all 50 United States. Alarmingly, the cancer incidence and mortality rates in Appalachian Kentucky are far higher than the rates for the non-Appalachian area of the state. These elevated rates are driven by a variety of underlying factors including low socioeconomic status, low educational attainment, high risk behaviors, cultural barriers, and environmental exposures. Strengths of the CP program include studies focused on uncovering the role environmental exposures play in Kentucky's high cancer incidence rates, testing intervention programs that address unique cultural barriers, and smoking cessation policy development initiatives. CP program members are also national leaders in developing population-based methods and measures that facilitate inter-programmatic cancer research. The CP program combines these strengths to address 3 thematic areas: identification of social, cultural, behavioral, genetic and environmental factors that contribute to the elevated cancer incidence and mortality rates (Theme 1); design, testing, implementation and evaluation of intervention strategies that address identified risk factors (barriers) and reduce the cancer burden (Theme 2); and development of population-based methods and measures that facilitate inter-programmatic cancer research directed at more precisely identifying the distribution of treatment patterns and biomarkers in the population (Theme 3). Most recently, the CP program recruited 2 National Cancer Institute-funded cancer molecular epidemiologists to build on its unique research resources. The current 28-member CP team draws from 5 colleges and 12 departments at the University of Kentucky, thus promoting active interdisciplinary translational research. CP productivity is reflected by total annual external cancer-related funding of over $9.7M ($6.7M annual direct costs) and 245 total publications in the current funding period, 30 (12%) of which are inter-programmatic, 83 (34%) intra-programmatic and 162 (66%) inter-institutional. CP research encompasses all segments of the cancer control continuum: prevention, early detection, treatment and survivorship. CP studies address a number of cancer sites including those that disproportionately contribute to Kentucky's high cancer burden (i.e. lung, colon, breast and cervical cancers). Thus, the CP program is integral to achieving the overall MCC mission to reduce cancer morbidity and mortality in the Commonwealth.