CSHL 2022 Neurodegenerative Diseases: Biology & Therapeutics Conference

摘要 神经退行性疾病：生物学与治疗学 2022年11月30日-12月3日 该提案寻求对两年一度的神经退行性疾病会议的支持： 生物学与治疗学，于2022年11月30日至12月3日在冷泉港举行 实验室(CSHL)。这次会议聚集了研究基础和基础研究的科学家 阿尔茨海默病、帕金森氏症等神经退行性疾病的翻译研究 疾病和肌萎缩侧索硬化症。对于这些疾病中的许多，分子 疾病过程的途径仍然不清楚，因此很少有生物标志物被 已确认身份。对于其他疾病，现有的治疗方法主要是为了缓解 症状，而没有解决退化过程背后的生物学问题。翻译 因此，需要研究来开发和验证新的诊断策略以及新的 可能阻止或阻止疾病进展的治疗方法，而不是简单地缓解症状。 会议将通过提供一个论坛来促进神经退行性变方面的知识 来自不同实验室和机构的科学家，无论是学术界还是产业界，都可以交流 发现、想法和寻求合作。它将包括关于融合和发散的会议 神经退行性疾病的通路、神经胶质生物学、治疗策略、载脂蛋白E和脂质 新陈代谢、细胞生物学和蛋白质动态平衡。用于寻求新治疗方法的人体研究 为了让神经退行性变具有信息量，研究不同的 这些治疗的各个方面定期在CSHL这样的环境中会面，交换数据和 想法。2022年CSHL神经退行性疾病：生物学和治疗学会议将 在前几届CSHL会议成功的基础上，召集一次顶级国际会议 科学家，讨论该领域的新发展，并催化创新研究 合作，所有这些最终都将加快发现的步伐。

ABSTRACT Neurodegenerative Diseases: Biology & Therapeutics November 30 - December 3, 2022 This proposal seeks support for the biennial conference on Neurodegenerative Diseases: Biology & Therapeutics, from November 30 – December 3, 2022 at Cold Spring Harbor Laboratory (CSHL). The meeting brings together scientists who investigate both basic and translational aspects of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. For many of these disorders, the molecular pathways of the disease processes remain unclear and thus few biomarkers have been identified. For other disorders, existing treatments are designed primarily to provide relief from symptoms without addressing the biology underlying degenerative processes. Translational research is therefore needed to develop and validate novel diagnostic strategies as well as new therapeutics that might halt or stem disease progression, rather than simply alleviate symptoms. The conference will advance knowledge in neurodegeneration by providing a forum where scientists from distinct laboratories and institutions, both academic and industry, can exchange findings, ideas, and seek collaborations. It will include sessions on convergent and divergent pathways in neurodegenerative diseases, glial biology, therapeutic strategies, APOE and lipid metabolism, cell biology, and protein homeostasis. For human studies seeking new treatments for neurodegeneration to be informative, it is essential for scientists who research different aspects of those treatments to meet regularly in a setting like CSHL to exchange data and ideas. The 2022 CSHL meeting on Neurodegenerative Diseases: Biology & Therapeutics will build on the successes of prior CSHL meetings to assemble an international gathering of top scientists, discuss new developments in the field, and catalyze innovative research collaborations, all of which will ultimately accelerate the pace of discovery.