13th International Particle Toxicology Meeting

摘要 与溶解相比，颗粒污染对生物系统的影响是完全不同的 化学制品。组织和细胞中独特的相互作用带来了挑战，也带来了发现的机会 -用于研究和风险评估。颗粒毒理学的科学已经很成熟了，但正在出现的问题 继续推进这一领域。自2019年在奥地利萨尔茨堡举行上次会议以来，我们经历了 全球范围内出现的众多颗粒物毒理学威胁：最近野火烟雾暴露的增加， 微塑料污染的必然性，飞沫和口罩功效的问题，电子烟 毒性，以及纳米材料的新的工程进展。这些问题和其他问题需要保持警惕 科学界更好地了解对医疗、公共卫生和生态造成不利影响的可能性 影响。我们将在新墨西哥州圣达菲主办第十三届国际颗粒毒理学会议(IPTC) 2022年8月28日至30日。IPTC一直是交流创新成果的重要场所 自1979年开始在颗粒毒理学领域举办，此后大约每3年举办一次。在2.5天内 会议期间，我们将听取主旨演讲者和特邀演讲者的发言，并为研究人员和受训人员提供场所 通过口头和海报演示分享他们的工作。面对面的网络，这是 实习生和年轻调查人员的职业发展是以下会议亟需的一个方面 SARS-CoV-2大流行的两年。作为会议的一个附加组成部分，一个互动的预 将为受训人员举办会议讲习班，以提供该领域专家关于颗粒物的培训 从监管和药物开发的角度进行安全评估。IPTC指导委员会是 此外，还关注气候变化及其在我们已经面临的许多问题中所起的作用。 野火、塑料和与能源相关的燃烧源PM将在 气候变化和主旨演讲者已被特别挑选出来向全球和长期 颗粒物毒理学展望。总体而言，IPTC的成功将通过实现三个主要目标来实现。 首先，从多个角度更广泛地分享与颗粒物相关的多个实验室/项目的关键发现 物质毒性、微塑料、野火烟雾和其他新兴概念。二、新经济发展 协作、多学科的研究计划。第三，推进职业发展道路 实习生和初级教员。会议结束时，我们将在指导委员会内开展工作， 主旨演讲/受邀演讲者和其他感兴趣的各方交流最新的科学手稿， 详细说明新出现的问题和新方法，以最好地解决颗粒毒理学研究。这篇论文将 帮助推动创新和协作，从而极大地推动该领域的发展。

SUMMARY Particulate contamination represents a wholly different impact to biological systems compared to dissolved chemicals. The unique interactions in tissues and in cells creates challenges – and opportunities for discovery – for research and risk assessment. The science of particle toxicology is well established, but emerging issues continue to advance the field. Since the last meeting in 2019 in Salzburg Austria, we have experienced numerous particle toxicology threats arising on a global scale: the recent increase in wildfire smoke exposures, the inevitability of microplastics contamination, questions about “droplets” and mask efficacy, e-cigarette toxicity, and novel engineering advances for nanomaterials. These issues and others require vigilance from the scientific community to better understand the potential for adverse medical, public health, and ecological impacts. We are hosting the 13th International Particle Toxicology Conference (IPTC) in Santa Fe, New Mexico from August 28-30th, 2022. The IPTC has been an important venue for the communication of innovations in the field of particle toxicology since 1979, and has been held roughly every 3 years since. Over the 2.5-day conference, we will hear from Keynote and Invited speakers, and provide a venue for researchers and trainees to share their work through oral and poster presentations. Face-to-face networking, an essential facet of career development for trainees and young investigators, is a much-needed aspect of the meeting following the 2 years of SARS-CoV-2 pandemic. As an additional component to the meeting, an interactive pre- conference workshop for trainees will be conducted, to provide training from experts in the field on particulate safety assessment from a regulatory and drug development standpoint. The IPTC Steering Committee is additionally focused on climate change and the role that plays in many of the problems we are already facing. Wildfires, plastics, and energy-related combustion-source PM will be topics covered within the context of a changing climate, and Keynote speakers have been specifically chosen to speak to the global and long-term outlook for particulate toxicology. Overall, the success of the IPTC will be achieved by meeting 3 major Aims. First, a broader sharing of key findings from multiple labs/programs on multiple angles related to particulate matter toxicity, microplastics, wildfire smoke, and other emerging concepts. Second, the development of new collaborative, multidisciplinary research initiatives. And third, advancing career development pathways for trainees and junior faculty. At the conclusion of the meeting, we will work within the Steering Committee, Keynote/Invited speakers, and other interested parties to communicate a state-of-the-science manuscript that details emerging issues and novel approaches to best address research on particle toxicology. This paper will help motivate innovation and collaboration to greatly advance the field.