Molecular Biology Across Scales Training Program

项目摘要/摘要 跨尺度分子生物学(MBA)是一项新的多学科博士前培训计划，将 培养下一代研究人员，发现分子、细胞和组织如何相互作用创造生命 以及这些信息如何促进人类健康。MBA将是该大学唯一的研究生课程 加州伯克利分校，支持分子生物学多学科的广泛培训，而不是 某一特定学科的专业化。这种观点推动了许多变革性的生物学 最近几年的发现，包括MBA教职员工的几项发现。MBA将吸引它的学生和教职员工 来自分子与细胞生物系(MCB)研究生项目，团结那些 从单个分子到复杂生化的长度尺度的基础研究问题 整个生物体的系统。它将任命40名学生(每年20名一年级实习生，为期两年)， 30%的目标来自生物科学中历史上被排除在外的群体。MBA将提供多样化的培训 为其多样化的学生群体提供机会，鼓励每一名学员在 他们的早年，并找出那些最充分地发挥个人激情的人。MBA学生将被要求 发表第一作者论文并以平均5.5年的时间毕业。这门课程将传授 广泛的概念性知识，创造性和批判性思维，掌握实验逻辑和方法， 应用计算和定量方法，严格分析和解释结果，明确 并流畅地沟通调查结果，并纳入负责任、安全和道德的做法。学生们将 从75名国家公认的领导者中挑选经过正式培训的导师，他们代表着广泛的选择 研究领域和技术方法，使用最先进的设施，并在互动，多样化的工作 和协作环境。MBA将为其参与的教职员工提供培训、监督和支持，以及 将密切关注其实习生的进度。全纳学习将为学生提供良好的支持 社区、严格而明确的期望、专家建议和考虑以下因素的程序设计 准备工作上的差异。创新的培训元素包括新的课程和增强的内容 负责任地进行研究和重复性，数量生物学和数据科学，实验室安全，以及 科学写作。为了进一步加强招聘和留住，MBA学生将采取措施促进多样性， 公平、包容和归属。将试行和评估新计划，目标是最大限度地扩大规模 这些活动的成功将惠及母婴健康中心的所有受训人员。专业技能发展，体验式学习 机会和职业咨询将使受训人员为他们在 学术界、工业界、政府、非政府组织等。总而言之，MBA将提供一个 早期并始终如一地强调多学科培训，以学生体验为中心，为 和个人导向的在生物医学劳动力中成功职业生涯的道路。

Project Summary / Abstract Molecular Biology Across Scales (MBAS) is a new multidisciplinary predoctoral training program that will develop the next generation of researchers discovering how molecules, cells, and tissues interact to create life and how this information can advance human health. MBAS will be the only graduate program at the University of California, Berkeley that supports broad-based training in multiple disciplines of molecular biology, rather than specialization within a particular discipline. This perspective has driven many of the transformative biological discoveries of recent years, including several made by MBAS faculty. MBAS will draw its students and faculty from the Department of Molecular & Cell Biology (MCB) Graduate Program, uniting those who tackle fundamental research problems at length scales ranging from individual molecules to complex biochemical systems to whole organisms. It will appoint 40 students (20 first-year trainees annually for a two-year term) with a target of 30% from historically excluded groups in the biological sciences. MBAS will provide diverse training opportunities for its diverse student body, encouraging each trainee to explore a wide range of research fields in their early years and identify those that most fully engage their individual passion. MBAS students will be required to publish a first-author paper and graduate with a mean time to degree of 5.5 years. The curriculum will impart broad conceptual knowledge, creative and critical thinking, mastery of experimental logic and methods, application of computational and quantitative approaches, rigorous analysis and interpretation of results, clear and fluent communication of findings, and incorporation of responsible, safe, and ethical practices. Students will choose formally-trained mentors from a faculty of 75 nationally recognized leaders who represent a wide choice of research areas and technical approaches, use state-of-the-art facilities, and work in an interactive, diverse and collaborative environment. MBAS will provide training, oversight, and support for its participating faculty, and will carefully monitor the progress of its trainees. Students will be well-supported with inclusive learning communities, rigorous and clear expectations, expert advising, and a program design that accounts for differences in preparation. Innovative training elements include new courses and enhanced content in responsible conduct of research and reproducibility, quantitative biology and data science, lab safety, and scientific writing. To further strengthen recruitment and retention, MBAS will mount initiatives to bolster diversity, equity, inclusion, and belonging. New programs will be piloted and evaluated with the goal of scaling the most successful of them to benefit all trainees within MCB. Professional skills development, experiential learning opportunities, and career counseling will prepare trainees for research-related careers of their choosing in academia, industry, government, non-governmental organizations, and beyond. In sum, MBAS will provide an early and persistent emphasis on multidisciplinary training, centered around the student experience, for a flexible and individually directed path to a successful career in the biomedical workforce.