Interdisciplinary Anesthesiology Research Training Program

摘要 麻醉学是一门跨学科的医学专业，要求其从业人员拥有广泛的资金， 知识，包括药理学，生理学和工程学，以及将这些知识应用于 无论是紧急情况还是控制情况。除了为学员提供卓越的临床知识外， 和技能，麻醉学系以及更大的学术界在大学 加州圣地亚哥分校（UCSD）为高质量的研究培训提供了世界一流的环境。两 UCSD的基础科学研究优势包括药理学系和 工程.包括基础科学家和临床医生在内的麻醉学家有着富有成效的互动， 与这两个学科的教师合作。因此，本次更新T32补助金申请的主要目标 仍然需要在麻醉科培养下一代临床科学家，以解决 通过利用潜在的跨学科培训， 与药理学和工程学院合作。这些互动作为指导， 研究员;然而，研究员与他们的指导团队有能力在更大的范围内， 合作者在最广泛的层面上进行研究，以涉及尽可能多的学科， 充分回答所提出的问题。这一目标将继续通过接近小学促进 麻醉问题与跨学科的培训重点;然而，该计划将保持灵活性， 随着研究员兴趣的发展，扩大研究范围。这项培训补助金将提供研究生 实习生（MD或MD/PhD），具有2年的研究经验，包括广泛关注基础 药物作用的分子机制和/或各种工程学科的探索。重点将 应用工程学原理，为治疗干预定义药物作用的新机制 创建设备，使用数学和理论方法建立生理学和病理生理学模型， 研究生物材料，以促进非侵入性监测，并产生生物特征和血液来源 生物数据，以及其他项目，以提高人类健康和病人的经验。实现这一 总的目标是，培训有两个具体目标：一）使研究员接触科学文化， 调查目前在该部门具体和校园广泛和ii）实现能力， 研究生涯的相关元素，例如实验设计，数据分析，演示文稿，手稿 准备和出版以及如何最好地获得研究资金以及实验室管理和工作 面试技巧我们非常强调研究环境中的协作和道德。实现我们 我们坚定地致力于临床科学家的发展，我们压倒一切的使命是培养 拥有知识基础和基本工具的下一代临床科学家 有着对转化研究的热情和承诺。

Abstract Anesthesiology is an interdisciplinary medical specialty requiring its practitioners to have a broad fund of knowledge, including pharmacology, physiology, and engineering and the ability to apply this knowledge in both controlled and emergency situations. In addition to providing trainees with exceptional clinical knowledge and skills, the Anesthesiology Department as well as the larger academic community at the University of California, San Diego (UCSD), provides a world-class environment for high quality training in research. Two particular basic science research strengths at UCSD include the Departments of Pharmacology and Engineering. Anesthesiologists including both basic scientists and clinicians have productive interactions and collaborations with faculty in these two disciplines. Thus, the primary goal of this renewal T32 grant application remains to train the next generation of clinician scientist in the Department of Anesthesiology to address important questions in the discipline by leveraging the potential interdisciplinary training available in collaboration with faculty in pharmacology and engineering. These interactions serve as guidance for our fellows; however, fellows with their mentoring team have the ability to work beyond, within, and in larger collaboratives to undertake research at the broadest level to involve as many disciplines necessary to adequately address the questions asked. This goal will continue to be facilitated by approaching primary questions in anesthesia with an interdisciplinary training focus; however, the program will remain flexible to expand research scope as the interests of fellows develop. This training grant will provide post-graduate trainees (MDs or MD/PhDs) with a 2-year research experience consisting of a broad focus on the basic molecular mechanisms of drug action and/or exploration of a variety of engineering disciplines. Emphasis will be on defining novel mechanisms of drug action for therapeutic interventions, applying engineering principles to create devices, model physiology and pathophysiology using mathematical and theoretical approaches, investigate biomaterials to facilitate non-invasive monitoring, and generation of biometric and blood derived biological data, among other projects to enhance human health and the patient experience. To achieve this overall goal, the training experience has two specific aims: i) expose fellows to a culture of science and investigation present in the Department specifically and the campus broadly and ii) achieve competency in the allied elements of a research career, e.g. experimental design, data analyses, presentations, manuscript preparation and publication and how best to obtain research funding as well as lab management and job interview skills. We strongly emphasize collegiality and ethics in the research environment. In achieving our strong commitment to the development of the clinician scientist, our overriding mission is the training of the next generation of clinician scientists who have the foundation of knowledge and fundamental tools coupled with the passion and commitment to affect translational research.