Next-Generation Multifunctional Nanoparticles for mRNA Transfection

该项目旨在设计一种专为mRNA递送而设计的多功能纳米颗粒平台。一种创新的组装方法将用于设计具有可调成分、不对称性和表面形貌的纳米颗粒。独特的是，三种功能将整合在一个纳米颗粒中，目的是提高靶细胞的转染效率。该项目预计将推进mRNA转染机制的知识，并确定细胞类型依赖性颗粒-mRNA相互作用如何与纳米颗粒结构和递送性能相关。结果包括一个新的功能材料家族，其mRNA递送性能优于基准系统，以促进和拓宽mRNA技术的应用。

This project aims to engineer a multifunctional nanoparticle platform tailored for mRNA delivery. An innovative assembly approach will be used to design nanoparticles with adjustable composition, asymmetry and surface topography. Uniquely, three functions will be integrated in one nanoparticle, with the goal to enhance transfection efficiency in target cells. This project expects to advance knowledge of mRNA transfection mechanisms, and determine how cell-type dependent particle-mRNA interactions correlate with the nanoparticle structure and delivery performance. Outcomes include a new family of functional materials with improved mRNA delivery performance over benchmark systems to facilitate and broaden the application of mRNA technology.