PHARMACOLOGICAL EFFECTS OF FLUORIDE

氟在公共供水中的公共卫生使用 龋齿的预防在世界范围内被接受， 以这种方式在痕量浓度中使用它已经多次被 记录在案。 已证实的氟化物的防龋活性导致 含氟产品的广泛使用， 随着氟化物的使用越来越多，问题也就不足为奇了。 关于这种药剂的安全性问题继续被提出。 该项目的总体目标是开发更多的 科学信息，以确保继续安全使用氟化物， 牙科公共卫生 该方案涉及三个项目， 三个核心单位提供适当的行政支助， 生物统计学和实验室分析。 项目#1旨在 研究氟化物可能的药理学和遗传毒性作用 与终生摄入最佳或高水平的 饮用水中的氟化物，摄入氟化物对医学的影响- 患有糖尿病或慢性肾功能衰竭的儿童和成人 失败，以及用于治疗的大剂量氟化物的影响 骨质疏松 项目#2使用受控动物模型进行研究 各种医学危害状况的影响（即，老化， 糖尿病、肾衰竭和营养不良）对 氟化 项目#4将研究慢性营养不良的影响 氟在人群中药理作用的不足之处 居住在中华人民共和国和厄瓜多尔的团体。

The public health use of fluoride in communal water supplies for the prevention of dental caries is accepted worldwide and the safety efficacy of its use in trace concentrations in this manner have been repeatedly documented. The proven cariostatic activity of fluoride has resulted in the widespread of fluoride-containing products to further and this increasing use of fluoride, it is not surprisingly that questions pertaining to the safety of this agent continue to be raised. The overall goal of this Program Project is to develop additional scientific information to assure the continued safe use of fluoride for dental public health. The Program involves three projects with the appropriate support provided by three core units for administration, biostatistics, and laboratory analyses. Project #1 is designed to investigate the possible pharmacologic and genotoxic effects of fluoride associated with lifetime ingestion of optimal or elevated levels of fluoride in the drinking water, effects of fluoride ingestion in medically- compromised children and adults afflicted with diabetes or chronic renal failure, and the effects of massive dosages of fluoride used to treat osteoporosis. Project #2 utilizes controlled animal models to investigate the impact of various medically-compromising conditions (i.e., aging, diabetes, renal failure and malnutrition) upon the pharmologic effects of fluoride. Project #4 will investigate the effect of chronic nutritional inadequacies upon the pharmacologic effects of fluoride in population groups residing The Peoples Republic of China and in Ecuador.