CATALYSIS AND MECHANISM

前提是生物有机化学领域的新突破是 不太可能是进一步细化大循环模型系统的结果， 我们已经开始了一项用新分子设计催化剂的计划 形状。因此，我们开发了结构主题，从这些主题中可以 各种裂隙状分子可以以模块化的方式制备。 这些具有催化作用的官能团聚合到 为高能中间体的过渡态提供补充。 它们的酸碱类似于许多酶活性部位。 官能团的性质和表现形式。这些都已经准备好了 协同催化，但通过使用 刚性隔板元件。逼真的阵列是为合成而开发的 核酸酶、蛋白水解酶、歧化酶和氧化桥联双铁中心。 预计这些研究将继续对 合理药物设计的机理和结构基础。

With the premise that radical new departures in bioorganic chemistry are unlikely to result from further elaboration of macrocyclic model systems, we have embarked on a program to devise catalysts from new molecular shapes. Accordingly, we have developed structural motifs from which a variety of cleft-like molecules can be prepared in modular fashion. These feature catalytically useful functional groups which converge to provide complements to transition states of high-energy intermediates. They resemble a number of enzyme active sites in their acid-base character and presentation of functional groups. These are poised for concerted catalysis, but kept from direct interaction through the use of rigid spacer elements. Realistic arrays are developed for synthetic nucleases, proteases, dismutases and oxobridged diiron centers. It is expected that these studies will continue to contribute to the mechanistic and structural foundations of rational drug design.