EMOTIONAL REACTIVITY AND ANTERIOR BRAIN ASYMMETRY

本申请中提出的研究旨在检查个人 前路激活的电生理测量方法的差异 不对称性及其与情绪和情感变化的关系 反应性。这项研究旨在复制和扩展最近的 我们实验室的发现表明前激活 不对称性随着时间的推移是稳定的，可以预测情绪和情感反应。 前不对称被认为是一种素质，与前向不对称相结合 必备的环境诱导剂，会偏向情绪反应。正确的 基线期间的前部激活预示着更大的负面影响 对合适的激发子的反应，同时激活左前部 预测结果正好相反。这些基本发现将扩展到两个大的 学习。在每项研究中，由156名受试者组成的独立队列将 三次对前部不对称的基线测量进行评估。 三个节段的前向不对称性与 对积极和消极情绪电影片段的反应性，寒冷的加压痛 被构建为产生失败的认知任务将被评估 在这两项研究中。此外，个人之间的关系 前部不对称的差异与细胞免疫功能的测定 将进行研究以确认和扩展我们的初步发现，这些发现表明 极右翼受试者自然杀伤细胞活性降低 额叶激活与表现为最左侧额叶的受试者的比较 激活。前部不对称的个体差异及其相互关系 还将评估令人震惊的震级，以检验以下假设 右前部激活程度较大的受试者将表现为突出 与左前部激活的对应者相比，令人震惊的程度。

The research proposed in this application is designed to examine individual differences in electrophysiological measures of anterior activation asymmetry and their relation to variations in mood and affective reactivity. The research is designed to replicate and extend recent findings from our laboratory which indicate that anterior activation asymmetries are stable over time and predict mood and affective reactivity. Anterior asymmetry is viewed as a diathesis, which in combination with the requisite environmental elicitor, will bias emotional reactivity. Right anterior activation during baseline predicts greater negative affect in response to an appropriate elicitor, while left anterior activation predicts the reverse. These basic findings will be extended in two large studies. In each study, an independent cohort of 156 subjects will be assessed on baseline measures of anterior asymmetry on three occasions. Relations between anterior asymmetry across the three sessions and reactivity to positive and negative emotional film clips, cold pressor pain and a cognitive task constructed to produce failure will be evaluated across the two studies. In addition, relations between individual differences in anterior asymmetry and measures of cellular immune function will be studied to confirm and extend our initial findings which indicate decreased natural killer cell activity in subjects with extreme right frontal activation compared to subjects showing extreme left frontal activation. Relations between individual differences in anterior asymmetry and startle magnitude will also be assessed to examine the hypothesis that subjects with greater right anterior activation will show accentuated startle magnitude compared with their left anterior activated counterparts.