LUNG DISEASE IN CHINESE TEXTILE WORKERS

这项提议有两个目标：[1]完成15年的纵向 研究上海纺织工人，中国和[2]来考查一个幼稚 年入境时和头三年的纺织工人人数 就业。这项提议旨在解决悬而未决的问题 关于长期接触有机污染物的工人的呼吸健康 灰尘和内毒素。暴露在革兰氏阴性细菌内毒素下 在实验室研究中被描述为会产生急性呼吸道症状 和肺功能的改变。类似的观察结果还没有重现。 在实际的磨机设置中。到目前为止，还没有其他前瞻性流行病学研究 已经解决了棉尘和内毒素在 产生急性和慢性呼吸道影响。重要的是 引起肺部影响的内毒素不仅在棉花中很重要 纺织业，但也在许多其他环境中 在那里会遇到大量空气传播的内毒素。 第一个目标是关注已经被研究的人群 自1981年以来一直被跟踪，非常适合于流行病学研究 原因是：流动率低，女性员工的吸烟率很低， 可靠的基线数据，适合在同一研究中的对照组 时尚，行业官员、工会和 协作性的。研究团队，接触已退休或离开的受试者 该行业的残疾，和成本效益。人口包括一名 第一批447名棉纺工人和465名丝纺工人 在1981年进行的调查。在1986年和1992年进行了跟踪调查， 90%的成功率。这项拟议的研究是独一无二的，因为暴露于 粉尘和内毒素在15年内都可以评估 粉尘和内毒素的暴露-反应关系 学习间歇。 为达致续期申请的第二个目标，我们建议 扩大研究范围--超越原来的队列，招募400名受试者 对磨坊曝光太天真了。我们有丰富的机会访问和测试 已经被雇用，但还没有接触棉尘的志愿者 以确定可能是离开风险标志的早期反应 这份工作和发展慢性呼吸道疾病。这个机会 之所以存在，是因为上海纺织业的用工做法 独一无二。我们将招聘2名棉花工人和200名丝绸新员工， 评估他们暴露前的支气管反应性、特应性和基线 呼吸健康。然后，我们将在前三年密切跟踪他们 有症状的工作、肺功能(交班)和 粉尘/内毒素测定。

This proposal has two objectives: [1] to complete a 15-year longitudinal study of textile workers in Shanghai, China, and [2] to examine a naive population of textile workers at entry and during the first three years of employment. This proposal is designed to address unanswered questions regarding the respiratory health of workers chronically exposed to organic dust and endotoxin. Exposure to gram-negative bacterial endotoxin has been described in laboratory studies as producing acute respiratory symptoms and lung function change. Similar observations have not been reproduced in actual mill settings. To date, no other prospective epidemiologic study has addressed the relative contributions of cotton dust and endotoxin in producing both acute and chronic respiratory effects. The importance of endotoxin in causing pulmonary effects is important not only in Inc cotton textile industry, but also in a number multitude of other environments where significant levels of airborne endotoxin are encountered. The first objective is focused on a study population that has been followed since 1981 and is unusually well-suited for epidemiologic study due to: low turnover, very low smoking prevalence among women workers, reliable baseline data, a suitable comparison group studied in identical fashion, excellent cooperation among industry officials, union and the collaborative'. research team, access to subjects who have retired or left the industry in disability, and cost-efficiency. The population includes a closed cohort of 447 cotton textile and 465 silk textile workers first surveyed in 1981. Follow-up surveys were conducted in 1986 and 1992 with 90% success. The proposed study is unique because exposure estimates for both dust and endotoxin over a 15-year period allow assessment of exposure-response relationships for both dust and endotoxin for the full study interval. To address the second objective in this renewal application, we propose to expand the study - beyond the original cohort and recruit 400 subjects naive to mill exposures. We have a rich opportunity to access and test volunteers who have been hired, but not yet exposed to cotton dust in order to determine early responses that may be markers of risk for leaving the job and for developing chronic respiratory disease. This opportunity exists because the Shanghai Textile Industry's employment practices are unique. We will recruit 2()() cotton and 200 silk newly-hired workers, assess their pre-exposure for bronchial responsiveness, atopy and baseline respiratory health. We will then follow them closely for the first 3 years of employment with symptoms, pulmonary function (cross-shift) and dust/endotoxin measurements.