NEGATIVE COGNITION DEPRESSION--ETIOLOGY AND COURSE

这一修订后的竞争延续是两个站点协作的一部分 相同金额的研究补助金(预算/人员除外) 天普·劳伦·B·合金博士同时提交的申请 以同样的头衔上大学。这两个项目都需要继续提供资金 完成该项目的网站。 先前的研究并没有为绝望提供充分的测试。 抑郁症的理论(HT)和贝克理论(BT)，可能非常 误导这些认知理论的有效性。调查人员已经 未能认识到这些类型的方法的含义 理论中规定的因果关系(例如，素质-压力， 异质性)，并且这些理论假设存在一个， 到目前为止，抑郁症的亚型还没有确定--“消极认知 抑郁症“(NCD)。因此，这项合作的首要目标是 该项目将为HT和BT的预测提供更强大的测试 关于NCD的人种学和这一亚型的验证。 为此，一项为期两年的大规模前瞻性研究旨在测试 HT和BT的病因假说在两个地点都在进行中。 目前，352名原本非抑郁、非精神病的SS Who 在面试评估中处于高或低认知风险 应激性生活事件、认知和精神状态/症状 以预测首发和随后的复发/复发 抑郁症。在接下来的部分中，将对此样本进行3次跟踪 党卫军从青春期后期过渡到 成人期。这一持续的跟踪将允许进行HT和BT的测试 在青春期晚期、成年期早期和过渡期 在这两个发育阶段之间。的连续性和变化性 认知方式和随之而来的抑郁症易感性的变化将 接受检查。认知的家族起源和发展起源 此外，还将研究抑郁症的易感性。党卫军的父母会 被招募参加终生精神病理学、认知能力评估 风格和父母反馈风格。 这些研究将有助于：1)科学地理解 情绪障碍的一个子集的行为学，2)更有效的 抑郁障碍，3)对抑郁症的起源和 抑郁症认知易感性的连续性/改变，以及4) 非传染性疾病等疾病的防治干预研究进展 大萧条。

This revised competing continuation is part of a 2-site collaborative research grant with an identical (except for budget/personnel) application submitted concurrently by Dr. Lauren B. Alloy of Temple University under the same title. Continued funding is required at both sites to complete the project. Prior research does not provide an adequate test of the hopelessness theory (HT) and Beck's theory (BT) of depression and may be very misleading about these cognitive theories' validity. Investigators have failed to appreciate the methodological implications of the kinds of causal relations specified in the theories (e.g., diathesis-stress, heterogeneity) and that these theories hypothesize the existence of an, as yet, unidentified subtype of depression- "negative cognition depression" (NCD). Thus, the overarching goal of this collaborative project is to provide a more powerful test of HT' and BT's predictions about the ethiology of NCD and a validation of this subtype. To this end, a large scale, 2-year prospective study designed to test the etiological hypotheses of HT and BT is underway at both sites. Currently, 352 originally non-depressed, non-psychopathological Ss who are at either high or low cognitive risk for interview assessments of stressful life events, cognition, and psychiatric status/symptoms in order to predict onsets and subsequent relapses/recurrences of depression. In the continuation, this sample will be followed for 3 additional years as the Ss make the transition from late adolescence to adulthood. This continued follow-up will allow for a test of HT and BT during late adolescence, early adulthood, and the transition period between these two developmental periods. The continuity and change of cognitive style and attendant change in vulnerability to depression will be examined. Familial and developmental origins of cognitive vulnerability to depression also will be examined. Parents of Ss will be recruited for an assessment of lifetime psychopathology, cognitive style, and parental feedback style. These studies will contribute to: 1) the scientific understanding of the ethology of a subset of the mood disorders, 2) a more valid nosology of the depressive disorders, 3) an understanding of the origins and continuity/change of cognitive vulnerability to depression, and 4) the development of intervention for treating and preventing NCD and other depressions.