FIFTH E COLI AND SMALL GENOMES MEETING--1997

描述：（申请人摘要）本提案是一项会议补助金 第五个E大肠杆菌和小基因组会议于10月12日至15日举行， 1997年在犹他州雪鸟的会议中心。 急诊大肠杆菌基因组计划是最早启动的计划之一， 今年完成的测序将是迄今为止最大的基因组测序， 是正在研究的典型基因组大小的两倍，例如H.流感 第一个完成的原核基因组。 广泛的生理， 生化和遗传分析。在过去的四十年里， 这是对原核生物最好的研究， 与其他人相比。 更大的基因组本身 承诺将有更广泛的功能进行分析， 这保证了E.大肠杆菌将继续提供先例和范例 对于原核和真核系统。 有很大的兴奋超过 前景是比较多达15个的序列和内容 原核生物基因组，以及E.预计大肠杆菌 在这一分析中占有重要地位。 相当大的整合， 微生物学的不同方面无疑会发生，包括新的 对进化和生命需求的看法。 为了实现这些目标，特别是一体化和协同作用， 来自不同学科的人必须相互作用。 本次会议将包括 活跃的基因组研究人员，如测序专家和信息学 从事数据库设计、序列分析或模拟的专家; 遗传学家开发新方法来利用基因组信息， 例如功能分析;细胞生物学家和生物化学家， 专门研究基因组学的成熟领域，如新陈代谢、染色体 结构或基因调控。 虽然最近有一些 基因组会议，继续完成和发布新的基因组 序列和发展势头分析这一巨大的数额 信息意味着社区继续需要这种会议。 这次会议已成为唯一的定期年度细菌 基因组学会议在过去5年中，并已保证的地位和 质量.

DESCRIPTION: (Applicant's Abstract) This proposal is for a conference grant for the Fifth E. coli and Small Genomes Conference to he held October 12-15, 1997 at the conference center in Snowbird, Utah. The E. coli genome project was one of the first initiated and when it is completed this year will be the largest genome sequenced to date, nearly 2.5 times the size of typical genomes under study such as H. influenzae, the first prokaryotic genome to be completed. The extensive physiologic, biochemical, and genetic analysis of E. coli over the last four decades make this the best studied of prokaryotic organisms and one of the model systems to which all others are compared. The larger size of the genome in itself promises that there will be a wider range of functions to be analyzed, and this guarantees that E. coli will continue to provide precedent and paradigm for both prokaryotic and eukaryotic systems. There is great excitement over the prospect of comparing the sequences and contents of as many as 15 prokaryotic genomes over the next year or two, and E. coli is expected to occupy a prominent place in this analysis. Considerable integration of different aspects of microbiology will undoubtedly take place, including new perspectives on evolution and the requirements for life. To achieve these goals, particularly of integration and synergy, scientists from diverse disciplines must interact. Thus this conference will include active genome researchers, such as sequencing experts and informatics specialists working in database design, sequence analysis, or simulation; geneticists developing new methods to take advantage of genomic information, e.g. for functional analysis; and cell biologists and biochemists who have specialized in areas now ripe for genomics such as metabolism, chromosome structure, or gene regulation. While there have been a number of recent genome conferences, continuing completion and release of new genome sequences and developing momentum for analysis of this huge amount of information means the community has continued need of such conferences. This meeting has become established as the only regular annual bacterial genomics conference during the last 5 years and has assured status and quality.