Molecular mechanisms of signalling by plant immune receptors

该项目旨在了解抗性蛋白的功能，并寻找这些蛋白的新来源。植物病害占全球作物产量损失的15%，对粮食安全构成威胁。杀菌剂是一种关键的保护形式，代表了环境问题。另一种关键的保护形式与抗性基因育种相对应，这受到育种过程漫长、从性相容物种中选择基因受到限制以及田间有效时间短的限制。在以往研究的基础上，本项目旨在描述Toll/白细胞介素-1受体结构域介导的烟酰胺腺嘌呤二核苷酸（NAD+）裂解的分子基础和植物NLR复合物的结构结构。这些知识将支持保护作物免受病原体侵害的长期目标。

This project aims to understand how resistance proteins function and to find new sources of these proteins. Plant diseases account for 15% loss of global crop production, representing a threat to food security. Fungicides, one key form of protection, represent environmental concerns. The other key form of protection corresponds to resistance gene breeding, which is limited by lengthy breeding processes, restricted choice of genes from sexually compatible species and short effective time spans in the field. Building on previous research, this project aims to characterise the molecular basis of the Toll/interleukin-1 receptor domain-mediated nicotinamide adenine dinucleotide (NAD+) cleavage and the structural architecture of plant NLR complexes. This knowledge will support the long-term objective of protecting crops from pathogens.