NEW BIOLOGIC FUNCTIONS OF PTHRP

这项研究计划的目标是评估新的生物功能 甲状旁腺激素相关肽（PTHrP）。这将是 通过评估生物活性， 甲状旁腺/甲状旁腺相关肽（PTH/PTHrP）在C57 BL-6中的体内 小鼠选择的PTH/PTHrP激动剂和拮抗剂的作用将 评价：1）诱导生长期毛发生长终期 小鼠，2）抑制生长期小鼠中的退化期毛发成熟，和3） 维持生长期小鼠的生长期毛发生长。的第二个目标 这项研究计划是评估生物活性， PTH/PTHrP激动剂和拮抗剂对毛发的作用机制 在培养的毛囊和C57的器官毛发培养物中生长 BL-6小鼠、PTHrP基因敲除小鼠、PTHrP受体敲除小鼠和它们的 正常的小伙伴

The goal of this research program is to evaluate new biologic functions of parathyroid hormone related peptide (PTHrP). This will be accomplished by evaluating the biologic activities of parathyroid/parathyroid related peptide (PTH/PTHrP) in vivo in C57 BL-6 mice. The effect of selected PTH/PTHrP agonists and antagonists will be evaluated on the: 1) induction of anagen hair growth in telogen mice, 2) inhibition of catagen hair maturation in anagen mice, and 3) maintenance of anagen hair growth in anagen mice. The second goal of this research program is to evaluate the biologic activity and mechanism of action of PTH/PTHrP agonists and antagonists on hair growth in cultured hair follicles and in organ hair cultures from C57 BL-6 mice, PTHrP knockout mice, PTHrP receptor knockout mice and their normal litter mates.