MAPPING OF CLEFT LIP AND PALATE IN MICE

人/小鼠同源图谱提供了一个很好的工具， 与人类疾病有关的候选基因 研究已经 开始使用几个新发现的人类基因座， 面部裂缝的候选人 协同 博士埃里克森，我们已经使用了标记在同源位置， 小鼠来寻找影响面部裂开的QTL。 搜索 鉴定了小鼠3号染色体上与人1 q21同源的区域， 当A/J菌株等位基因为 礼物 由于A/J菌株具有许多 散发性CL 9 P的发病率高于C57 B16 J菌株， RI系的其它祖系。

The human/mouse homology map provides an excellent tool to identify candidate genes involved in human disease. Studies have been initiated using several newly identified loci in man that are candidates for involvement in facial clefting. In collaboration with Dr. Erikson, we have used markers for homologous positions in the mouse to search for QTLs affecting facial clefting. The search identified a region of mouse chromosome 3 homologous to human 1q21 as increasing liability to sporadic CL(P) when the A/J strain allele is present. This effect might be expected since the A/J strain has much higher incidence of sporadic CL9P) than does the C57B16J strain, the other progenitor strain of the RI lines.