组胺释放机制-猫眼课题宝

组胺释放机制

批准号：

2572227

负责人：

R P SIRAGANIAN

金额：

$0.0万

依托单位：

NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/2572227

关键词：

antibody receptor basophils biological models biological signal transduction calcium channel histamine release immunoregulation inflammation ionophores leukocyte activation /transformation mast cell neoplastic cell culture for noncancer research phosphorylation protein tyrosine kinase secretion tissue /cell culture

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中文摘要

翻译

肥大细胞和嗜碱性粒细胞释放组胺的研究，一种与炎症有关的免疫机制。激活这些细胞的免疫细胞表面受体也是一个模型，信号转导和细胞分泌。除了细胞表面受体，细胞可以被其他促分泌素激活，钙离子载体A23187。过去几年的重点是在了解蛋白质酪氨酸磷酸化的作用在信号。培养的大鼠嗜碱性白血病细胞，作为这些研究的主要模型之一。

英文摘要

Histamine release from mast cells and basophils is being studied as an immunological mechanism involved in inflammation. The activation of these cells by immune cell surface receptors is also a model for signal transduction and cell secretion. Besides cell surface receptors, the cells can be activated by other secretagogues such as the calcium ionophore A23187. The emphasis the last few years has been in understanding the role of protein tyrosine phosphorylations in the signalling. The cultured rat basophilic leukemia cells are used as one of the main models for these studies.

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