FIBER OPTIC SENSOR FOR FEMALE REPRODUCTIVE HORMONES

尽管众所周知，绝经后妇女的许多医学问题 与生殖激素水平的变化有关， 测量多种荷尔蒙可避免常规监测 当一个女人经历她的生殖阶段。这导致的结果是 了解与以下相关的副作用的生理基础 激素替代疗法。Innovation Associates建议追求 第二阶段同时测量光纤传感器的研制 血清雌二醇、孕酮、卵泡刺激素、促黄体生成素的变化。本仪器的使用 医生办公室将降低测量成本，同时提供 在几分钟内，结果与临床化验结果相当。 在第一阶段，Innovation Associates展示了光纤 传感器可以在感兴趣的生理范围内使用 时间分辨荧光。这将扩展到同步 在第二阶段测量多种激素。时间分辨率允许 将荧光与天然血清荧光分离，以便 可以对未经处理的血清进行检测。光纤传感使 不需要物理分离自由结合的荧光。同舟共济 这些方法为开发工具提供了基础 医生办公室、医院所需的速度和简洁性 床边和现场应用程序。 拟议的商业应用：专为医生办公室设计， 医院床边和现场情况，一种简单的低成本光纤 传感器将广泛应用于多种激素、药物、传染病 毒剂和代谢物。它将立即产生效果，并已 由所选卡扣式探头确定的物质测量的灵活性 由医生设计的这一系列传感器探头中的第一个将包括 产科和妇科专家感兴趣的生殖激素 妇科。

Although it is known that many medical problems of postmenopausal women relate to changes in levels of reproductive hormones, the cost of measuring multiple hormones prevents them from being routinely monitored as a woman passes through her reproductive phases. This results in little understanding of the physiological basis for side effects associated with hormone replacement therapy. Innovation Associates proposes to pursue Phase II development of a fiber optic sensor for simultaneous measurement of estradiol, progesterone, FSH and LH in serum. Use of this instrument in physician's offices will reduce measurement costs while providing, within minutes, results comparable to those obtained from clinical assay. During Phase I, Innovation Associates demonstrated that a fiber optic sensor can assay estradiol in the physiological range of interest using time resolved fluorescence. This will be extended to simultaneous measurement of multiple hormones in Phase II. Time resolution permits fluorescence to be separated from natural serum fluorescence so that assay can be performed on unprocessed serum. Fiber optic sensing makes physical separation of free from bound fluorescence unnecessary. Together these methods provide the basis for development of an instrument offering the speed and simplicity required for physician's office, hospital bedside and field applications. PROPOSED COMMERCIAL APPLICATION: Designed for physicians' offices, hospital bedside, and field situations, a simple low cost fiber optic sensor will have wide application to many hormones, drugs, infectious agents and metabolites. It will give immediate results and has flexibility for measuring substances determined by snap in probes chosen by the physician The first in this family of sensor probes will include reproductive hormones of interest to specialists in obstetrics and gynecology.