PANCREATIC CANCER CASE CONTROL STUDY IN SAN FRANCISCO

研究人员建议对男性进行一项以人群为基础的病例对照研究 和妇女检验与外分泌腺癌有关的假说 胰腺和详细的职业史和化学暴露(见 特别是氯代烃和芳香胺)、饮食、香烟 吸烟、过敏和其他因素。青枯病的分子遗传学研究 将进行CYP2D6基因座的多态调查 遗传危险因素在香烟新陈代谢中的可能作用 衍生的化学致癌物有患胰腺癌的风险。这项研究将 包括所有患有外分泌腺癌的患者 年龄在21岁到85岁之间，会说英语或西班牙语，住在 在确诊时在旧金山湾区的六个县。1000例 在3.5年的案件中，1150名控制人员将接受采访- 确认期。正在进行的快速病例查明方法，使用 医院出院名单和病理实验室，将被用于 在两周内找到研究区域内的胰腺癌患者 诊断。患者的病理幻灯片将由一名高年级学生审查 加州大学旧金山分校(UCSF)病理学家。 控制将使用随机数字拨号进行识别，并将使用频率 按性别和5岁年龄组与病例匹配。每个黑色有两个控件 而西班牙裔患者将获得足够的统计数据 其他每个患者都将获得权力和一个控制。 65岁以上的控制组将从以下名单中随机挑选 医疗保健融资管理局除了从以下几个选项中选择 普通民众。将进行有组织的个人面谈 由训练有素的采访者在研究对象家中或在方便的地方 直指主题。采访主题将包括：详细信息 职业、化学和工业接触、饮食、医疗和 过敏史、用药情况、家族史或胰腺癌以及 其他相关条件、人口和其他因素。血液样本 基因研究将由抽血师在受试者的 家。血清将储存在零下40度的等分中，细胞样本 将与液氮一起冷冻保存在欧文纪念血液中 银行。全血样本也将被储存起来，用于未来的遗传和 生物标志物研究。分析将使用单变量和 仔细关注潜力的多元统计 混血儿。

The investigator propose a population-based, case-control study in men and women to examine hypotheses linking adenocarcinoma of the exocrine pancreas and detailed occupational history and chemical exposures (in particular chlorinated hydrocarbons and aromatic amines), diet, cigarette smoking, allergies, and other factors. A molecular genetic study of polymorphisms at the CYP2D6 gene locus will be conducted to investigate the possible role of genetic risk factors in the metabolism of cigarette- derived chemical carcinogens in pancreatic cancer risk. The study will include all patients with adenocarcinoma of the exocrine pancreas who are between the ages of 21 and 85, who speak English or Spanish, and who live in the six-county San Francisco Bay Area at time of diagnosis. 1000 cases and 1150 controls will be interviewed during the 3.5 year case- ascertainment period. Ongoing rapid case ascertainment methods, using hospital discharge lists and pathology laboratories, will be employed to locate pancreatic cancer patients in the study area within two weeks of diagnosis. Pathology slides for patients will be reviewed by a senior pathologist at the University of California San Francisco (UCSF). Controls will be identified using random digit dial and will be frequency matched to cases by sex and 5-year age group. Two controls for each black and Hispanic patient will be obtained to achieve adequate statistical power and one control will be obtained for each of the other patients. Controls over age 65 years will be randomly selected from the rolls of the Health Care Financing Administration in addition to those chosen from the general population. Structured personal interviews will be conducted by trained interviewers in study subjects' homes or at a place convenient to the subject. Interview topics will include: detailed information on occupations and chemical and industrial exposures, diet, medical and allergy history, medication use, family history or pancreatic cancer and other relevant conditions, demographic and other factors. Blood samples for genetic investigation will be drawn by phlebotomists in the subjects' homes. Serum will be stored in aliquots at -40 degrees and cell samples will be stored frozen with liquid nitrogen in the Irwin Memorial Blood Bank. Whole blood specimens also will be stored for future genetic and biomarker studies. Analyses will be conducted using univariate and multivariate statistics with careful attention paid to potential confounders.