Atomic scale precision engineering of cell-material interfaces

本计画旨在借由x光绕射及分子模拟来确定新型胜肽自组装体与细胞膜界面的分子结构。该项目将产生知识，使肽纳米材料的原子级工程，并利用这些材料来调节细胞反应。预期成果包括设计具有特定化学和物理线索的肽纳米结构，以促进所需细胞的可持续生长，同时抑制不良反应。这些结果应该提供的好处，在一个实用的工具包，为定制的肽纳米结构的结构和功能，并开辟了一个新时代的智能生物材料的分子设计。这个易于扩展的新材料平台将为澳大利亚新兴的高价值制造业做出贡献。

This project aims to determine the molecular structure of the interface between novel peptide self-assemblies and cell membranes through x-ray diffraction and molecular simulation. The project will generate knowledge to enable atomic scale engineering of peptide nanomaterials, and exploitation of these materials to modulate cell responses. Expected outcomes include designed peptide nanostructures with specific chemical and physical cues to promote sustainable growth of desired cells, whilst inhibiting undesirable responses. These outcomes should provide benefits in terms of a practical toolkit for tailoring structure and function of peptide nanostructures and open up a new era in molecular design of smart biomaterials. This easily scalable, new materials platform will contribute to emerging high-value manufacturing industries in Australia.