Age-related mechanisms of amino acid signalling in skeletal muscle

该项目旨在增加我们对甘氨酸受体介导的信号传导及其代谢在调节肌肉蛋白质合成的关键酶mTORC1的氨基酸感知能力中的作用的理解。衰老与骨骼肌质量的逐渐下降、无力和损伤后再生受损有关。食物摄入后的合成代谢信号受损被认为是一个关键因素，但负责营养感知和蛋白质合成调节的代谢途径仍未得到解决。该项目将评估老年哺乳动物有缺陷的氨基酸感知和蛋白质合成，确定甘氨酸信号在这些过程中的作用。该项目预计将支持肌肉动态平衡的肌肉特异性调节剂的发展，与澳大利亚人口老龄化广泛相关。

This project aims to increase our understanding of the role of glycine receptor-mediated signalling and its metabolism in the amino acid sensing capacity of mTORC1, a key enzyme regulating muscle protein synthesis. Ageing is associated with a progressive decline in skeletal muscle mass, weakness, and impaired regeneration after injury. Impaired anabolic signalling after food intake has been proposed as a key contributor, yet the metabolic pathways responsible for nutrient sensing and regulation of protein synthesis remain unresolved. The project will assess defective amino acid sensing and protein synthesis in old mammals, identifying the role of glycine signalling in these processes. The project expects to underpin development of muscle-specific modulators of muscle homeostasis with broad relevance to Australia’s ageing population.