EXERCISE DOSE FOR CARDIOVASCULAR HEALTH OF OBESE YOUTHS

描述：拟议研究的长期目标是 确定心血管（CV）健康的最佳运动剂量。 的 具体目的是检验两个假设：（1）8个月的体能训练 (PT)将增强肥胖青年的CV健康，（2）高强度PT将 比低强度PT更有效。 13-16岁肥胖奥尔兹（n=180）将 随机化，在性别和种族内（黑人/白色），进入对照组，低 强度和高强度组。 所有小组将接受标准护理 (i.e.饮食和运动信息），PT组接受 此外，PT控制。 主要结果变量是脂肪百分比 （用双X射线吸收测定法测量）。 静息代谢、饮食和 将测量自由生活的身体活动（用双标记水）。 冠心病（CHD）的一系列危险因素将在 评估，包括内脏脂肪组织（磁共振 成像）和左心室尺寸（超声心动图）。 自我概念和自我效能将被测量，以了解 干预措施的心理影响。 心率将保持在低水平 （110-130 bpm）或高（160-180 bpm）强度区域，能量消耗 保持不变。 将使用所有受试者的数据对假设进行检验， 不管是否遵守规定的治疗方案。 后期测试将是 在最后一次PT会议后的早晨，以确定PT的影响 在经常锻炼的肥胖青年中。 为了确定长期影响 一套完整的评估将在8个月内完成， 干预结束后。 这项研究将提供明确的 关于运动对肥胖青年影响的数据。 这些信息 将有助于制定青少年治疗方案， 肥胖，对冠心病的一级预防有意义。

DESCRIPTION: The long-term objective of the proposed research is to establish the optimal dose of exercise for cardiovascular (CV) health. The specific aims are to test two hypotheses: (1) 8 months of physical training (PT) will enhance CV health of obese youths, (2) high intensity PT will be more effective than low intensity PT. Obese 13-16 year olds (n=180) will be randomized, within gender and ethnicity (black/white), into control, low intensity and high intensity groups. All groups will receive standard care (i.e. diet and exercise information), with the PT groups receiving controlled PT in addition. The primary outcome variable will be percent fat (measured with dual x-ray absorptiometry). Resting metabolism, diet and free-living physical activity (with doubly labeled water) will be measured. A comprehensive set of risk factors for coronary heart disease (CHD) will be assessed, including visceral adipose tissue (with magnetic resonance imaging) and left ventricular dimensions (with echocardiography). Self-concept and self-efficacy will be measured to gain insight into psychologic effects of the interventions. Heart rates will be kept in low (110-130 bpm) or high (160-180 bpm) intensity zones, with energy expended held constant. The hypotheses will be tested with data from all subjects, regardless of adherence to the prescribed regimens. The post-test will be on the morning following the last PT session to determine the impact of PT in obese youths who exercise regularly. To determine the longer-term effect of the interventions, a complete set of assessments will be made 8 months after termination of the interventions. This study will provide definitive data concerning the effect of exercise in obese youths. This information will contribute to the development of programs for treatment of adolescent obesity, with implications for primary prevention of CHD.