CONDUCT DISORDER IN ADOLESCENT GIRLS--PATHS TO ADULTHOOD

科学发展奖（SDAC）的申请名为 “青春期女孩的行为障碍：成年之路。“我的小学 感兴趣的是青春期女孩的行为途径， 行为障碍（CD）进入成年早期及以后。最近的证据 出现的建议，a）在青春期女孩比 以前认识到，成人的结果往往是特点 严重的社会和精神功能障碍，即使没有关联， 公然犯罪我们对它的发展轨迹知之甚少， 与各种结果相关的路径，或者基线因素可能 在将女孩置于特定结果的风险中很重要。更不 这些女性的成年发展阶段是已知的。 研究项目1包括对现有数据集的二次分析- - 匹兹堡青年研究研究中1500名男孩的母亲将 根据以下情况，被诊断为无CD、可能CD或确定CD 以前收集的关于反社会行为的信息， 青春期这些妇女从1987年起每年接受一次随访 到现在他们的心理功能，社会质量 人际关系、育儿技巧、就业和教育历史， 犯罪行为，物质使用和病史将被跟踪， 这个时间段。除了衡量这些妇女在 在任何一个时间点，数据将用于探索随机模型 来描述通向不同结果的路径。 研究项目2是一项对65名CD女孩的对照前瞻性研究 和65名无CD的女孩（N= 130），将根据 精神稳定性，神经心理功能，睾酮， 雄烯二酮和雌二醇、脱氢表雄酮（DHEA）及其硫酸盐 （DHEA（-S）和性类固醇结合球蛋白（SSBG）血浆水平，测量 身体和间接攻击，并在人际关系中发挥作用， 关系。这些参数将在年度评估中进行跟踪， 三年，超过了最初的评估。 综合起来，这些项目跨越了从青少年到 成年早期，提供数据来完善将被测试的假设， 在一项针对青春期女孩的大型、基于一般人群的调查研究中， 的CD。SDAC的最终目标是准备一个应用程序， 资助这样的项目。

This application for a Scientist Development Award SDAC) is entitled "Conduct Disorders in Adolescent Girls: Paths To Adulthood." My primary interest is in the behavioral pathways taken by adolescent girls with Conduct Disorder (CD) into early adulthood and beyond. Recent evidence has emerged to suggest that a) in adolescent girls is more common than previously realized, and that the adult outcomes are often characterized by significant social and psychiatric dysfunction, even when not associated with overt criminality. Little is known about the developmental tracks or paths associated with the various outcomes, or what baseline factors may be important in placing a girl at risk for a particular outcome. Even less is known about the stages of adult development in these women. Research Project 1 consists of secondary analyses of an existing data set - - the Pittsburgh Youth Study. The mothers of 1500 boys in the study will be assigned a diagnosis of No CD, Probable CD, or Definite CD, based on information previously collected about antisocial behavior during their adolescence. These women have been followed at yearly intervals from 1987 to the present. Their psychological functioning, quality of social relationships, parenting skills, employment and education histories, criminal behavior, substance use and medical histories will be tracked over this time period. In addition to measuring the outcomes for these women at any one point in time, the data will be used to explore stochastic models to describe the paths taken to various outcomes. Research Project 2 is a controlled, prospective study of 65 girls with CD and 65 girls without CD (N= 130) who will be compared on the basis of psychiatric stability, neuropsychological function, testosterone, androstenedione, and estradiol, dyhydroepiandrosterone (DHEA), its sulfate (DHEA(-S) and sex steroid binding globulin (SSBG) plasma levels, measures of physical and indirect aggression, and functioning in interpersonal relationships. These parameters will be tracked in yearly evaluations for three years, beyond the initial assessment. In combination, these projects span the life cycle from adolescence to early adulthood, providing data to refine hypotheses that will be tested in a large, general population-based longitudinaI study of adolescent girls with CD. The final goal of the SDAC is to prepare an application for funding such a project.