COMPREHENSIVE PROTEIN DATABASE FOR YEAST S CEREVISIAE

蛋白质组数据库，包含所有蛋白质的属性和功能 由基因组编码的蛋白质已经为酵母构建而成 酿酒。酵母蛋白数据库(YPD)包含一个页面(YPD 蛋白质报告)在WWW(www.Proteome.com/YPDhome.html)上 6000种酵母菌蛋白。YPD的信息来源是基因组 序列和酵母文献，其中3000篇论文已被 已审阅。在接下来的两年里，关于酵母的文献综述 蛋白质将被完成，新的信息服务将被 已开发，包括增强的WWW演示文稿(YPD-Plus)和 自动通知服务。后一项服务将提醒用户 他们的兴趣档案中的新信息，并将自动 以用户指定的格式提供信息。最后，一个新的 信息呈现水平，YPD蛋白质简要评论，将是 实施以总结和扩展《青年发展报告》中提出的信息 蛋白质报告。这些小评论，每个都是由一位专家作者撰写的， 将包含指向YPD蛋白质报告的图形和超文本链接，其他 数据库和Medline摘要。YPD蛋白质报告平台 和YPD蛋白质微型评论将构成一个全面的信息 关于一个重要的蛋白质组的商业价值的资源 模型生物。在现代基因组学和蛋白质组学领域，模型 生物体数据经常被用来向新的 人类基因和蛋白质序列。 建议的商业应用 随着整个基因组序列变得可用，有可能 描述“蛋白质组”，或由基因组编码的一组蛋白质。 这项研究将有助于开发一个主要蛋白质组的内容 数据库，这将导致生物学的新的呈现形式 互联网上的信息。一个具有在线评论的蛋白质组数据库 与之相联系，将构成一个新的信息资源，具有商业价值 价值。目前关于酵母菌的工作应该成为 为包括人类在内的其他生物提供信息资源。

A proteome database, containing properties and functions for all the proteins coded by a genome, has been built for the yeast Saccharomyces cerevisiae. The Yeast Protein Database (YPD) contains a page (YPD Protein Report) on the WWW (www.proteome.com/YPDhome.html) for each of the 6000 yeast proteins. The information sources for YPD are the genome sequence and the yeast literature, of which 3000 papers have been reviewed. In the next two years, the literature review for yeast proteins will be completed and new information services will be developed, including an enhanced WWW presentation (YPD-Plus) and an automatic notification service. The latter service will alert users to new information within their interest profile and will automatically deliver the information in a user-specified format. Finally, a new level of information presentation, the YPD Protein Minireviews, will be implemented to summarize and extend the information presented in the YPD Protein Reports. These minireviews, each written by an expert author, will contain graphics and hypertext links to YPD Protein Reports, other databases, and Medline abstracts. The platform of YPD Protein Reports and YPD Protein Minireviews will constitute a comprehensive information resource of commercial value regarding the proteome of an important model organism. In the modern fields of genomics and proteomics, model organism data is constantly used to add functional information to new human gene and protein sequences. PROPOSED COMMERCIAL APPLICATION With entire genome sequences becoming available, it becomes possible to describe the "proteome," or the set of proteins coded by the genome. This research will help to develop the content of a major proteome database, and it will lead to new forms of presentation of biological information over the Internet. A proteome database with online reviews linked to it will constitute a new information resource with commercial value. The current work on yeast should serve as a model for information resources for other organisms including humans.