LONGITUDINAL STUDY IN PSYCHIATRIC EPIDEMIOLOGY

这项建议的目的是在最近收集的信息基础上再接再厉 作为精神疾病流行病学纵向调查的一部分 普通人群的成人样本。总体目标是提供 关于精神障碍的历史趋势的40年透视。 位于加拿大大西洋的这一地点已被命名为“斯特林” 保护身份。具体目标是继续 分析积累的数据并准备一系列报告 其中将描述研究结果，并在适当的情况下， 与最近的研究结果进行了比较。 这项研究涉及三次重复的横断面抽样调查(1952年， 1970年和1992年)和两个小组跟踪间隔(1952-1970年-和1970年- (1992年)。将报告有关流行率、发病率、 约4000名受试者的临床病程和死亡结果。 从一开始就收集了两种类型的信息 调查：1.)对受试者进行结构化访谈，内容涉及 抑郁、焦虑和健康状况。半结构化 精神病学家对被提名的全科医生的采访 受试者被问及这些患者的医疗和精神病史 研究对象。 最近的一波数据收集浪潮包括管理 NIMH诊断性面谈与修订的简易心理状态量表 考试。这些时间表的发现将有助于与研究进行比较 例如NIMH流行病集水区计划和国家 共病研究，特别是常见疾病的研究，如 抑郁、焦虑、酗酒和认知功能障碍 随着年龄的增长。 要调查的危险因素和趋势包括：出生队列 影响、老龄化、性别、妇女角色的变化、社会经济 身份、精神障碍家族史、婚姻和家庭 模式，宗教/种族认同，以及精神病患者之间的共病 和医学障碍，也在精神病学的范围内。这个 将调查卫生政策变化的影响，因为加拿大 全民健康保险在#年中期引入该地区。 学习间隔时间。数据分析将利用多变量 对数线性分析、生存回归和结构分析等技术 方程建模。精神病学诊断的可靠性和有效性将 被评估。

The purpose of this proposal is to build on information gathered recently as part of a longitudinal investigation of psychiatric epidemiology among adult samples of a general population. The overall objective is to provide a 40-year perspective on historical trends regarding psychiatric disorders. The site in Atlantic Canada has been given the pseudonym of "Stirling County" for protection of identity. The specific aims are to continue analysis of the accumulated body of data and to prepare a series of reports in which findings from the study will be described and, where appropriate, compared with those of recent studies. The study involves three repeated cross-sectional sample surveys (1952, 1970, and 1992) and two panel follow-up intervals (1952-1970- and 1970- 1992). Time trends will be reported regarding prevalence, incidence, clinical course, and mortality outcomes among approximately 4000 subjects. Two types of information have been gathered from the beginning of the investigation: 1.) structured interviews with subjects concerning depression, anxiety, and medical conditions.; and 2.) semi-structured interviews by psychiatrists with general physicians who have been named by subjects and asked about the medical and psychiatric histories of these subjects. The recent wave of data-gathering included administration of sections of the NIMH Diagnostic Interview Schedule and the Modified Mini-Mental Status Examination. Findings from these schedules will aid comparison to studies such as the NIMH Epidemiologic Catchment Area Program and the National Comorbidity Study, especially for common disorders such as those involving depression, anxiety, alcohol abuse, and cognitive dysfunction associated with aging. The risk factors and trends to be investigated include: birth cohort effects, aging, gender, changes in the role of women, socio-economic status, family history of psychiatric disorders, marriage and family patterns, religious/ethnic identity, and comorbidity between psychiatric and medical disorders and also within the psychiatric spectrum. The effects of health policy changes will be investigated since Canadian national health insurance was introduced into the area at the mid-point of the study interval. Analysis of data will make use of multivariate techniques such as loglinear analysis, survival regressions, and structural equation modelling. Reliability and validity of psychiatric diagnoses will be assessed.