USE OF BIOMARKERS TO MOTIVATE SMOKING CESSATION

非裔美国人，特别是男性，吸烟率很高， 与吸烟有关的癌症发病率也很高。最近的事态发展 鉴定烟草易感性的遗传标记 相关癌症提供了令人兴奋的机会， 个性化风险和增强动机的健康教育策略 为了戒烟。这项研究是一项为期五年的随机试验 评估提供生物标志物反馈的增量改善 科学的戒烟干预措施， 非裔美国人吸烟者戒烟的动机和可能性。 将在添加剂研究设计中测试三种干预条件。 在社区卫生诊所接受护理的患者， 主要是非洲裔美国人将接受吸烟筛查 在候诊室的状态，以确定当前吸烟者。的吸烟者 同意提供呼吸和血液样本，并参与吸烟 戒烟干预组（n=620）将被随机分为三组， 干预条件（1）自助指导加激励电话 咨询（加强al护理，n-160）;（2）自助指南加 动机定制反馈，包括呼出的一氧化碳（CO） 结果加上动机性电话咨询（暴露生物标志物 反馈，n=160）;（3）自助指南加定制反馈， 包括CO的检测结果和以下遗传生物标志物的存在： 肺癌易感性加激励性电话咨询 （易感性生物标志物反馈，n = 300）。 数据收集将包括 一个面对面的基线调查，电话随访调查，在6，12， 18个月，并收集唾液样本，以验证自我报告 禁欲感兴趣的主要结果将是退出的动机 每次随访时的吸烟、点患病率和持续戒烟率。 拟议的研究与整个项目主题密切相关， “改善癌症风险沟通。“CPRU的框架 使我们能够组建一个多学科的团队， 一起发展我们的沟通方式。经济学 CPRU核心固有的规模将允许我们将成本 有效性分析和可靠的生物统计资源， 成本

African Americans, particularly men, have high rates of smoking and concomitantly high rates of smoking-related cancers. Recent developments in the identification of genetic markers of susceptibility to tobacco related cancers provide exciting opportunities for developing innovative health education strategies that personalize risk and enhance motivation for smoking cessation. The proposed study is a five year randomized trial to evaluate the incremental improvement of providing biomarker feedback to state-of-the-science smoking cessation interventions to increase motivation and likelihood of cessation among African American smokers. Three intervention conditions will be tested in an additive study design. Patients who receive care at a community health clinic that serves a predominantly African American population will be screened for smoking status in the waiting rooms to identify current smokers. Smokers who agree to provide a breath and blood sample and take part in the smoking cessation intervention (n=620) will be randomized t one of three intervention conditions (1) Self-help guide plus motivational telephone counseling (Enhanced al care, n-160); (2) Self-help guide plus motivational tailored feedback that includes expired carbon monoxide (CO) results plus motivational telephone counseling (Exposure biomarker feedback, n=160); (3) Self-help guide plus tailored feedback that includes test results for CO and the presence of genetic biomarkers of susceptibility to lung cancer plus motivational telephone counseling (Susceptibility biomarker feedback, n-300). Data collection will include an in-person baseline survey, telephone follow-up surveys at 6,12, and 18 months, and collection of saliva samples to validate self-reported abstinence. The primary outcomes of interest will be motivation to quit smoking, point prevalence, and sustained abstinence at each follow-up. The proposed study is integrally linked to the overall project theme, "Improving Cancer Risk Communications." The framework for the CPRU enables us to assemble a multidisciplinary team that brings the best and brightest together to develop our communication approaches. The economics of scale inherent in the CPRU Cores will permit us to include cost effectiveness analysis and a solid biostatistical resource at modest cost.