SOLID STATE OPTICS FOR NONINVASIVE GLUCOSE MONITORS

该提案描述了一个研究计划，开发新的固态 工作在组合区的半导体光接收器 近红外光谱 这些接收器需要改进 用于无创血糖测量的光谱质量。 数据 表明葡萄糖可以选择性地在复合物中测量， 生物基质（未稀释的人血清和哺乳动物细胞培养物 介质）上收集的近红外光谱 区域（2.08到2.38）。 非侵入性的人类光谱收集在这个 波长范围缺乏足够的信噪比， 血糖测量。仪器分析显示， 探测器性能目前限制了我们的进展领域。 所以我们 建议专门开发低噪声、高响应度的探测器 专为这种应用和这种光谱范围而设计。 特别是 InGaAsSb合金将用于制造半导体探测器， 波长在2.08和2.38微米之间。 这种半导体材料 为该光谱范围提供了理想的带隙， 响应性 此外，该合金可以是晶格匹配的， 市售的GaSb衬底，这将使暗电流最小化。 将这些新颖的光电探测器直接与定制设计的 跨谐放大器电路将降低噪声。 所得 光接收器将为光谱提供极好的信噪比 在2.08至2.38微米之间收集。 该提案详细说明了 第一代接收器的制造和表征。 随后的几代将在光子的基础上建造， 电子和光谱性能。

This proposal describes a research plan to develop novel solid-state semiconductor photoreceivers for operation in the combination region of the near infrared spectrum. These receivers are necessary to improve spectral quality for noninvasive measurements of blood glucose. Data is provided to show that glucose can be measured selectively in complex biological matrices (undiluted human serum and mammalian cell culture media) for near infrared spectra collected over the combination spectral region (2.08 to 2.38). Noninvasive human spectra collected over this wavelength range lack sufficient signal-to-noise to permit accurate blood glucose measurements. Analysis of the instrumentation reveals that detector performance currently limits our progress area. Hence, we propose to develop low-noise, high responsivity detectors specifically designed for this application and this spectral range. Specifically the alloy InGaAsSb will be used to fabricate semiconductor detectors for wavelengths between 2.08 and 2.38 microns. This semiconductor material provides an ideal bandgap for this spectral range which will maximize responsivity. Furthermore, this alloy can be lattice matched to commercially available GaSb substrates that will minimize dark currents. Coupling these novel photodetectors directly with custom-designed transimpedance amplifier circuits will reduce noise. The resulting photoreceivers will provide excellent signal-to-noise ratios for spectra collected between 2.08 to 2.38 microns. This proposal details the fabrication and characterization of a first generation of receivers. Subsequent generations will be constructed on the basis of photonic, electronic and spectroscopic performance.