PATHOGENESIS OF NEUROBORRELIOSIS

莱姆氏疏螺旋体病(LNB)是一种日益流行的原因 世界上最大的神经系统疾病。感染会导致慢性 脑膜炎、脑神经损害、慢性记忆障碍和 认知功能和周围神经损伤。很少有 已知中枢神经系统感染的发病机制 系统(CNS)。这种对LNB发病机制的忽视 促使进行费力且过于昂贵的诊断程序，如 以及奇怪且经常有毒的治疗方法： 例如，我们不知道： 螺旋体在皮内侵入中枢神经系统的频率 注射法 感染在中枢神经系统持续多长时间 中枢神经系统细胞感染的类型和部位 免疫系统是否在中枢神经系统中发挥重要作用 感染 螺旋体是否侵入周围神经 这个项目将解决这些无知的领域，使用一个模型 恒河猴的LNB是我们实验室新近发现的。这个 所获得的信息将有助于理解AS的发病机制 以及基本诊断策略和安全的发展， 有效的治疗。它还将使我们更好地理解 中枢神经系统的慢性感染。

Lyme neuroborreliosis (LNB) is an increasingly prevalent cause of neurological disease in the world. The infection results in chronic meningitis, cranial nerve lesions, chronic disorders of memory and cognitive functioning, and peripheral nerve damage. Very little is known about pathogenesis of the infection in the central nervous system (CNS). This ignorance about the pathogenesis of LNB has prompted laborious and excessively expensive diagnostic procedures, as well as bizarre and frequently toxic treatments: For instance, we do not know: how frequently the spirochete invades the CNS after intradermal injection how long the infection persists in the CNS the CNS cell type and location infected whether the immune system plays a significant role in the CNS infection whether spirochetes invade peripheral nerves This project will address these areas of ignorance, using a model of LNB in Rhesus macaques recently developed in our laboratory. The information gained will lead to an understanding of pathogenesis as well as the development of rationale diagnostic strategies and safe, effective therapy. It will also lead to a greater understanding of chronic infections of the CNS.