LARYNGEAL FUNCTION IN RESPIRATION

在过去的五年里，首席研究员（PI）专注于 他对上呼吸道呼吸功能的关注。 正在进行 研究试图阐明调节呼吸的因素， 上呼吸道肌肉的相关活动。 此外，目前的工作 试图确定上呼吸道肌肉在发病机制中的作用 阻塞性睡眠呼吸暂停综合征的临床症状 UTMB加尔维斯顿的肺科向PI提供了 这是一个独特的机会，可以在三个方面寻求这些问题的答案。 重要领域：动物研究和临床研究 清醒和睡眠。 在接下来的五年里，PI寻求 发展他的动物、睡眠和临床呼吸控制实验室 成为一个综合网络，用于调查生理和 上呼吸道功能的病理生理学方面。 两个相关 未来五年的目标是：1）加强合作关系 与其他主要关注上气道功能的研究者 2）发展基础神经生理学的专业知识， 应用于研究上呼吸道的神经运动控制。 除了正在进行的阻塞性睡眠发病机制的研究外， 呼吸暂停，在未来五年的具体研究将集中在作用 喉在人类呼吸调节中的作用。 新 我们实验室开发的技术允许肌电描记 将从3个以前无法进入的地方定期获得录音 喉肌：甲杓肌、杓肌和后肌 环杓肌 支持此应用程序将允许应用程序 这些技术，以确定控制因素， 这些喉内肌的痉挛相关活动。 肌电记录与测量的相关性 喉气道阻力和声带位置将用于 确定1）控制的生理和病理生理因素 喉内肌的发音相关活动，以及2） 喉内肌活动变化的净效应 喉功能

Over the past five years, the principal investigator (PI) has focused his attention on the respiratory function of the upper airway. Ongoing research seeks to elucidate the factors which modulate the respiratory- related activity of upper airway muscles. In addition, current work seeks to determine the role of upper airway muscles in the pathogenesis of the clinical sleep disorder, obstructive sleep apnea. The Pulmonary Division at UTMB Galveston has provided the PI with the unique opportunity to pursue the answers to these questions in three important areas: animal research, and clinical research during both wakefulness and sleep. Over the next five years, the PI seeks to develop his Animal, Sleep and Clinical Control of Breathing Laboratories into an integrated network for the investigation of physiologic and pathophysiologic aspects of upper airway function. Two other related goals over the next five years are 1) to strengthen collaborative ties with other investigators with primary interests in upper airway function and 2) to develop the expertise in basic neurophysiology which will be applied to studying neuromotor control of the upper airway. In addition to ongoing work on the pathogenesis of obstructive sleep apnea, specific research over the next five years will focus on the role of the larynx in the regulation of respiration in humans. New techniques developed in our laboratory allow electromyographic recordings to be routinely obtained from 3 previously inaccessible laryngeal muscles: the thyroarytenoid, arytenoideus and posterior cricoarytenoid. Support of this application will allow the application of these techniques to determine the factors which control the respiratory-related activity of these intrinsic laryngeal muscles. Correlation of the electromyographic recordings with measurements of laryngeal airway resistance and vocal cord position will be used to determine 1) the physiologic and pathophysiologic factors which control the respiratory-related activity of intrinsic laryngeal muscles, and 2) the net effect of changes in intrinsic laryngeal muscle activity on laryngeal function.