DIAGNOSTIC RADIOLOGY-IMAGING-METABOLISM OF TUMOR

我们的动物研究的总体目标是评估各种 与MRI/31 p-MMR比较的体外功能和形态学参数 以及脑肿瘤生长和对类固醇治疗反应的PET数据。宠物 数据将包括血流量、耗氧量和 18F-2-氟-2-脱氧葡萄糖摄取。这些研究旨在 使用体内MRI/MRS和PET技术以及 建立体外测定程序。在犬类研究中，核磁共振成像和正电子发射断层扫描 将使用定位在相同动物上进行研究 将提供相同组织样本检查的技术 音量.两种非侵入性体内程序的结果将是 与体外详细的形态测定-组织学分析相关， 肿瘤以及脑/肿瘤组织比重测量， 使用微球技术的血流测定。高分辨率 （显微镜）成像程序将用于研究兔脑 肿瘤作为其生长和对治疗反应的函数， 减少肿瘤引起的水肿。MRI高分辨率图像将 与样品体积面积的详细组织学评价相比。 肿瘤相关水肿将使用TI和TI的测量值进行定量 T2弛豫时间并与肿瘤的直接体外测量进行比较 以及水肿性脑组织水含量、血浆蛋白外渗 以及血管-血管外空间隔室测定。的 拟议的研究将及时处理与以下方面有关的重要问题： 提供的信息和MRI/MRS的潜在临床应用 PET。

The overall goal of our animal studies is to evaluate how various in vitro functional and morphological parameters compare with MRI/31p-MMR and PET data of brain tumor growth and response to steroid therapy. PET data will include blood flow, oxygen consumptionand 18F-2-Fluoro-2-deoxyglucose uptake. The studies are designed to quantitate data using in vivo MRI/MRS and PET techniques as well as established in vitro assay procedures. In the canine work, MRI and PET studies will be performed on the same animals using localization techniques that will provide examination of the same tissue sample volume. The results of both non invasive in vivo procedures will be correlated to in vitro detailed morphometric-histological analysis of the tumors as well as brain/ tumor tissue specific gravity measurements and blood flow determinations using microsphere techniques. High resolution (microscopy) imaging procedures will be employed to study rabbit brain tumors as a function of their growth and response to therapy aimed at reducing tumor induced edema. The MRI high resolution images will be compared to detailed histological evaluation of the sample volume area. Tumor associated edema will be quantitated using measurements of Tl and T2 relaxation times and compared to direct in vitro measurements of tumor and edematous brain tissue water content extravasation of plasma proteins and vascular - extravascular space compartment determinations. The proposed studies address timely and important issues relating to the information provided and the potential clinical applications of MRI/MRS and PET.