The MC-Degradome; a gas-sensing proteome that controls plant development?

为什么有些蛋白质的寿命很短，但有时却可以变长？这项提议的重点是揭示控制蛋白质稳定性的机制，特别是对两种气体--氧气和信号分子一氧化氮(NO)的反应。我们将发现需要缺氧或无氧才能稳定的蛋白质。这一点很重要，因为在植物的生命周期中，以及在对环境变化的反应中(例如，在洪水期间)，当植物感觉到缺氧或没有氧气时，这是至关重要的。这项工作将揭示使植物对气体做出反应的分子过程，并提供分子资源和概念框架，植物育种者和种植者可以用来改变植物特征，使植物更适应气候变化。

Why is it that the life of some proteins is very short, but can sometimes become longer? This proposal focuses on uncovering the mechanisms controlling the stability of proteins, particularly in response to two gases, oxygen, and the signalling molecule nitric oxide (NO). We will discover proteins that require a lack of oxygen or NO to become stable. This is important because there are examples of times during the plant life-cycle, and in response to changes in the environment (for example during flooding) when it is essential that plants can perceive a lack of oxygen or NO. This work will uncover the molecular processes that allow plants to respond to gases and provide molecular resources and conceptual frameworks that plant breeders and growers can use to change plant traits and make plants more adapted to climate change.