COHORT STUDY OF DIET AND NASOPHYARYNGEAL CANCER

拟议在新加坡进行的队列研究的主要目标是 明确确定中国咸鱼为人类致癌物。 我们 具体目标是：（1）证明NPC的不同发病率 不同水平的中国咸鱼摄入量之间的差异， 招募，（2）建立中国咸鱼和类似的摄入量 食物是福建人患鼻咽癌的主要危险因素， 他们的风险比广东人低， 暴露水平，以及（3）进一步研究假设， 摄取富含微量营养素的食物，如新鲜蔬菜和水果 对NPC的发展起到了修正和有益的作用。 一 这项研究的第二个目标是建立一个稳定的队列， 长期研究饮食和其他环境因素之间的关系 癌症和其他慢性疾病的决定因素。 癌症部位 在4-7年内研究的足够病例包括肺、胃、结肠， 直肠和女性乳房。 一个由60，000名中国人组成的队列（每个队列中有15，000名 年龄介乎45至64岁， 新加坡的住宅小区将在24个月内招募。 一份强调饮食暴露的结构化问卷将 在招募时亲自给每位参与者服用。 则将队列 通过（1）每年通过电话再次联系，对癌症发生情况进行随访 所有研究受试者，（2）审查死亡登记记录，和（3） 审查癌症登记记录。

The primary goal of the proposed cohort study in Singapore is to definitively establish Chinese salted fish as a human carcinogen. Our specific aims are: (1) to demonstrate differential incidence rates of NPC between individuals at different levels of Chinese salted fish intake at recruitment, (2) to establish intake of Chinese salted fish and similar foods as a major risk factor for NPC among the Hokkien people and to show that their lower risk relative to the Cantonese is a result of their lower level of exposure, and (3) to further investigate the hypothesis that ingestion of micronutrient rich foods such as fresh vegetables and fruit exert a modifying and beneficial effect on the development of NPC. A secondary goal of this proposed research is to establish a stable cohort for long-term study of the relationship of dietary and other environmental determinants to cancer and other chronic diseases. Cancer sites with sufficient cases for study within 4-7 years include lung, stomach, colon, rectum, and female breast. A cohort of 60,000 Chinese (15,000 each of Cantonese and Hokkien men and women) aged 45-64 years and residing in Housing Estates in Singapore will be recruited over a period of 24 months. A structured questionnaire emphasizing dietary exposures will be administered in person to each participant at recruitment. The cohort will be followed for cancer occurrence through (1) annual recontact by telephone of all study subjects, (2) review of death registration records, and (3) review of cancer registration records.