COLOR VISION IN PRIMARY OPEN ANGLE GLAUCOMA

该提案概述了心理物理学研究技术，旨在研究 与初级开角相关的人类色觉变化 青光眼 更好地理解潜在的功能变化 在色觉引起的青光眼将解决通过测量罚款 沿彩色和消色差维度的沿着辨别。 使用本提案中描述的程序进行彩色视野检查， 发现成功区分可疑青光眼和原发性开角型青光眼 青光眼患者与正常年龄匹配的对照。 的长期随访 这些患者将决定测试预测哪些患者的能力。 高眼压的眼睛是最有风险的发展青光眼之前， 视神经盘和标准视野的地形变化 明显，以及该测试是否可用于监测医疗有效性 青光眼的治疗方法 最后，纳入了确定以下比例的方法： 由于标准白色上的正常老化而导致的灵敏度损失， 彩色视野 年龄相关变化的差异， 眼介质对光的吸收增加，以及视网膜色素变性引起的光吸收增加。 或者神经系统的变化都是可能的 这将提供新的信息， 有助于准确诊断和治疗。

This proposal outlines psychophysical research techniques designed to study the changes in human color vision associated with primary open angle glaucoma. An improved understanding of the underlying functional changes in color vision caused by glaucoma will be addressed by measurement of fine discriminations along both chromatic and achromatic dimensions. Color perimetry using the procedures described in this proposal has been found to successfully differentiate glaucoma suspect and primary open angle glaucoma patients from normal age-matched controls. Long-term follow-up of these patients will determine the ability of the test to predict which ocular hypertensive eyes are most at risk for development glaucoma before topographic changes in the optic disc and standard visual field become apparent, and whether the test can used to monitor effectiveness of medical therapies employed in glaucoma. Finally, methods are incorporated which will determine the proportion of sensitivity loss due to normal aging on both standard white-on-white and color visual fields. Differentiation of age-related changes due to increased absorption of light by the ocular media and those due to retinal or neural changes will be possible. This will provide new information to assist in accurate diagnosis and treatment.