How enhancers regulate T cell differentiation and function

该项目旨在确定调节有效免疫细胞分化所需的转录增强子活性的分子机制。适应性免疫细胞激活启动了一个分化程序，获得并维持特定血统的效应器功能。利用包括细胞和染色质生物学、高级生物信息学、靶向基因组编辑和纳米技术在内的多学科方法，该项目有望为非编码调控元件重新编程以及免疫细胞功能和记忆的控制提供见解，并对理解一般细胞分化产生影响。

This project aims to identify the molecular mechanisms that regulate the activity of transcriptional enhancers needed for effective immune cell differentiation. Adaptive immune cell activation starts a programme of differentiation that acquires and maintains lineage-specific effector function. Using a multidisciplinary approach including cellular and chromatin biology, advanced bioinformatics, targeted genome editing and nanotechnology, this project expects to provide insights into non-coding regulatory element reprogramming and control of immune cell function and memory with implications for understanding general cellular differentiation.