TOPOLOGY OF THE VISUALLY EVOKED POTENTIAL

视觉诱发的人的头皮拓扑结构之间的关系 将研究潜伏期(VEP)和导致它的刺激范式 使用一种允许对活跃皮质进行非侵入性定位的新方法 分辨率约为1厘米的人体区域。该方法基于 记录秒数估计头皮VEP视野的拉普拉斯 沿垂直方向的位场与A的差值 多电极阵列。基础神经生理学的以下几个问题 兴趣将涉及：(1)图案化刺激的皮质定位 呈现给视野的不同部分(视网膜检查图 大脑皮层)。(2)活动从属于视觉对象的皮层定位 承认。视网膜地图将被用来接近几个相关的 临床问题：(1)电极位置的选择 辨别VEP中黄斑中心凹信号对大视野刺激的帮助 不透明媒质、婴幼儿、脑损伤患者的评价 弱智患者，(2)电极放置方式的选择 从距离注视10度到25度的视野区域辨别信号 作为对现场缺陷的客观检测和监测的辅助工具 青光眼，(3)弱视患者偏心注视的客观测量 (4)偏视视野和象限视野的客观检测 神经眼科问题的缺陷。

The relationship between the scalp topology of the visually evoked potential (VEP) and the stimulus paradigm that causes it will be studied using a new method that allows noninvasive localization of active cortical areas in humans with a resolution of about 1 cm. The method is based on estimating the Laplacian of the VEP field on the scalp by recording second differences of the potential field along orthogonal directions from a multielectrode array. The following problems of basic neurophysiological interest will be addressed: (1) cortical localization of patterned stimuli presented to different parts of the visual field (retinotopic map of the cortex). (2) cortical localization of activity subserving visual object recognition. The retinotopic map will be used to approach several related clinical problems: (1) the selection of electrode placements to discriminate foveal signals in the VEP to wide field stimuli as an aid in the evaluation of patients with opaque media, infants, brain-damaged and mentally retarded patients, (2) the selection of electrode placements to discriminate signals from visual field zones 10 to 25 degrees from fixation as an aid to the objective detection and monitoring of field defects in glaucoma, (3) the objective measurement of eccentric fixation in amblyopia and (4) the objective detection of hemianopic and quadrantanopic field defects in neuroophthalmological problems.