EFFECT OF GROWTH FACTORS ON LENS CELLS IN CULTURE

这笔赠款代表了一种试图以系统的方式理解 控制生长和新陈代谢的各种激素和生长因子 培养中的晶状体细胞。研究的具体目的是：1) 研究调节晶状体细胞增殖的外部信号；2)获得 关于晶状体细胞表面受体性质的信息；3) 研究生长因子引起的初级生物反应；4) 查看跨单元传输信息的可能模型 5)利用遗传学手段探讨其作用机制。 增长因素。人们认为这种分子生长的方法 使用定义的外部信号的监管应产生重要的 关于白内障形成问题的信息。

This grant represents an attempt to understand in a systematic way, the various hormones and growth factors which control the growth and metabolism of lens cells in culture. The specific aims of the research are: 1) To study external signals that modify lens cell proliferation; 2) To obtain information on the nature of surface receptors on lens cells; 3) To investigate the primary biological response elicited by growth factors; 4) To look at possible models for the transfer of information across the cell membrane; 5) The use of genetics to approach the mechanism of action of growth factors. It is felt that this molecular approach to growth regulation using defined external signals should yield important information on the problem of cataractogenesis.