EXPERIMENTAL MYOPIA IN PRIMATES

这项研究的目的是澄清导致 近视的起源，并开发程序来预防这种情况。 我们已经证明，新生猕猴的手术眼睑融合会导致 一种轴向长度近视，非常类似于人类的屈光不正。 在恒河猴中，眼睛的伸长主要是由 破坏视网膜对眼睛生长的控制。在……里面 相比之下，短尾猴的眼睛伸长主要是由于 中枢神经系统通过过度调节。该应用程序是 涉及(A)视网膜释放的分子的鉴定/S 对恒河猴眼睛生长的调节并测试它们的效果 在体内和体外；(B)通过以下方法诱导短尾猴近视 通过行为控制迫使动物适应；(C)评估 视网膜和中枢神经系统对 这两种灵长类动物眼睑缝合近视的发病机制。

The objective of this study is to clarify the mechanisms responsible for the genesis of myopia and to develop procedures to prevent this condition. We have shown that surgical lid fusion in neonatal macaque monkeys causes an axial length myopia that is very similar to the human refractive error. In the rhesus macaque, elongation of the eye is primarily caused by disruption of the control of eye growth that is exerted by the retina. In contrast, eye elongation in the stump-tailed macaque is mainly due to the central nervous system through excessive accommodation. The application is concerned with (a) identification of the molecule/s released by the retina that modulate eye growth in the rhesus macaque and testing their effects both in vivo and in vitro; (b) inducing myopia in stump-tailed macaques by forcing the animal to accommodate through behavioral control; (c) assessing the relative contribution of the retina and central nervous system to the pathogenesis of lid-suture myopia in these two primate species.