BIOLOGICAL EFFECTS OF ULTRASOUND

这项研究的目的是确定疾病的程度和性质 低兆赫超声波与哺乳动物组织的相互作用。超音波 现在在临床诊断和治疗中都有非常广泛的应用。在……里面 这两种医学应用都为生殖组织提供了机会 暴露在显著水平的超声波下 一段时间是存在的。目前还没有进行研究来确定 可能发生的相互作用，并确定是否应谨慎 应扩大到那些施暴者和那些受到曝光的人。为 这些原因使哺乳动物的卵巢被选为特定的器官 以便在拟议的研究中进行调查。这项研究将涉及 确定功能和/或结构变化的阈值水平 出现在小鼠黄体上。在确定阈值和 吸收系数的测量，第二个剂量效应研究将 评估多次暴露。在这些研究之后，一个电子 显微镜研究和生育研究将完成。这是意料之中的 这项研究的结果将为评估风险提供基础 卵巢组织在治疗时暴露于超声波期间所引起的 以及在诊断级别和制度上。

It is the purpose of this study to determine the degree and nature of the interaction of low megahertz ultrasound and mammalian tissues. Ultrasound is now very widely used clinically both in diagnosis and in therapy. In both of these medical applications the opportunity for reproductive tissues to become exposed to significant levels of ultrasound for appreciable periods of time is extant. Studies have not been undertaken to determine the interactions that could occur and to determine whether or not cautions should be extended to those perpetrating and those receiving exposure. For these reasons the mammalian ovary has been selected as the specific organ for investigation in the proposed study. This study will involve determining threshold levels at which functional and/or structural changes occur to murine corpora lutea. Following identification of thresholds and measurement of absorption coefficients, a second dose-effect study will assess multiple exposures. Subsequent to these studies an electron microscopy study and a fertility study will be completed. It is expected that the results of this study will provide a basis for assessing risk incurred by ovarian tissues during exposure to ultrasound at therapeutic and at diagnostic levels and regimes.