FIVE-YR FOLLOWUP, GUBBIO STUDY--LCT, BP, OTHER VARIABLES

五年来对古比奥镇人口的重新审查 意大利中北部，旨在测试前瞻性假说 与钠刺激的锂逆向转运的作用有关 (LCT)，在1983-85年间测量，在随后的血液变化中 血压和高血压的发生率。在这么大的空间里 人口样本(5,376人，年龄在5-90岁之间，占已确定人口的92% 人口)，在基线上进行的测量也允许 LCT是否存在假设正相关关系的评估 对血压的影响不受年龄、性别、 体重指数、酒精摄入量、血尿酸、血糖、家庭 历史，以及通常与BP相关的其他变量。这个 这些因素的5年变化之间的关系， LCT，并在血压中也将检查。优势将 还将利用这个大型数据库来探索其他几个 血液流行病学中尚未解决的重要问题 血压和高血压：大量营养素和 LCT中的微量营养素及其变化；红细胞钠和 钾浓度及其与血压的关系；可能 高血压病患者与非高血压患者钙代谢的差异 血压正常者；与脂脂蛋白相关的遗传多态 新陈代谢及其对血压的可能影响；血型 老年人(即639岁和341岁)的压力变化 基线时分别为65-74和75+)。 古比奥研究的中心焦点是高血压，在 部分原因是高血压的患病率在这个地区很高 意大利小镇。但是，此外，它计划利用 古比奥形势为研究提供了难得的机遇 这一人群的冠心病发病率 冠状动脉危险因素明显发生了变化，达到了 等于或高于目前在美国流行的那些。 这项研究的下一阶段将与 古比奥、罗马和那不勒斯的同事。预计 顺利完成为期5年的跟踪检查 将为进一步的长期跟踪奠定基础。

Five-year re-examination of the population of Gubbio, a town in north central Italy, aims at testing prospectively hypotheses related to the role of sodium-stimulated lithium countertransport (LCT), measured in 1983-85, in subsequent change in blood pressure as well as incidence of hypertension. In this large population sample (5,376 persons age 5-90, 92% of the identified population), measurements made at baseline also permit assessment of whether the hypothesized positive relation of LCT to blood pressure (BP) is independent of such factors as age, sex, body mass index, alcohol intake, plasma uric acid, glucose, family history, and other variables generally associated with BP. The relationship between 5-year changes in these factors, change in LCT, and in blood pressure will also be examined. Advantage will also be taken of this large data base to explore several additional important unresolved questions on the epidemiology of blood pressure and hypertension: the role of macronutrients and micronutrients in LCT and its change; red blood cell sodium and potassium concentrations and their relation to BP; possible differences in calcium metabolism between hypertensives and normotensives; genetic polymorphisms related to lipid-lipoprotein metabolism and possible influence on BP; patterns of blood pressure change in the elderly (i.e., the 639 and 341 persons age 65-74 and 75+, respectively, at baseline). The central focus of the study in Gubbio is on hypertension, in part because the prevalence of high blood pressure is high in this Italian town. But, in addition, it is planned to take advantage of the unusual opportunity presented by the Gubbio situation to study coronary heart disease incidence in this population whose coronary risk factors have apparently changed, to reach levels equal to or above those currently prevalent in the United States. This next phase of the study will be done in collaboration with colleagues in Gubbio, Rome, and Naples. It is anticipated that successful accomplishment of the 5-year follow-up examination will lay the foundation for further long-term follow-up.