EMOTIONAL REACTIVITY AND ANTERIOR BRAIN ASYMMETRY

本申请中提出的研究旨在检查个人 前部激活的电生理测量的差异 不对称性及其与情绪和情感变化的关系 反应性 这项研究旨在复制和扩展最近的 我们实验室的发现表明， 不对称性随着时间的推移是稳定的，并预测情绪和情感反应。 前部不对称被认为是一种素质， 必要的环境诱导物，会偏向情绪反应。 权 基线时的前部激活预测了 对适当的激发子的反应，而左前激活 预测相反。 这些基本发现将在两个大的 问题研究 在每项研究中，将对156名受试者的独立队列进行研究。 在三种情况下对前部不对称的基线测量进行评估。 三个疗程中的前部不对称与 对积极和消极情绪电影片段的反应，冷加压疼痛 并评估一个为产生失败而构建的认知任务 在两项研究中。 此外，个人之间的关系 前部不对称和细胞免疫功能测量的差异 将进行研究，以确认和扩展我们的初步调查结果， 极右翼患者自然杀伤细胞活性降低 与显示极左额叶激活的受试者相比， activation. 前牙不对称个体差异的关系 和惊吓强度也将被评估，以检验假设， 右前激活更强的受试者将显示出 与其左前激活的对应物相比，

The research proposed in this application is designed to examine individual differences in electrophysiological measures of anterior activation asymmetry and their relation to variations in mood and affective reactivity. The research is designed to replicate and extend recent findings from our laboratory which indicate that anterior activation asymmetries are stable over time and predict mood and affective reactivity. Anterior asymmetry is viewed as a diathesis, which in combination with the requisite environmental elicitor, will bias emotional reactivity. Right anterior activation during baseline predicts greater negative affect in response to an appropriate elicitor, while left anterior activation predicts the reverse. These basic findings will be extended in two large studies. In each study, an independent cohort of 156 subjects will be assessed on baseline measures of anterior asymmetry on three occasions. Relations between anterior asymmetry across the three sessions and reactivity to positive and negative emotional film clips, cold pressor pain and a cognitive task constructed to produce failure will be evaluated across the two studies. In addition, relations between individual differences in anterior asymmetry and measures of cellular immune function will be studied to confirm and extend our initial findings which indicate decreased natural killer cell activity in subjects with extreme right frontal activation compared to subjects showing extreme left frontal activation. Relations between individual differences in anterior asymmetry and startle magnitude will also be assessed to examine the hypothesis that subjects with greater right anterior activation will show accentuated startle magnitude compared with their left anterior activated counterparts.