SPATIAL PROCESSING IN AUDITORY CORTEX

描述：(改编自申请人的摘要。)建议进行的研究 将使用二分法和自由场刺激相结合的方法来检查 单个神经元的双耳反应特性，并确定这些 响应属性决定了它们的声音位置选择性。录音 这些部位将被标记，以确定这些神经元是否在解剖学上 根据双耳特性或空间调谐来组织的。径向 通过皮质柱的穿透将决定 单个列中的响应属性。皮质表面将是 在两个维度上映射，以确定听觉类型是否在解剖学上 隔离，以及在每个听觉隔离中是否存在更精细的 职能组织层级。结果将与类似的结果进行比较 下丘研究反应的转化 从中脑到大脑皮层的特性和功能组织。 大脑皮质60千赫区域的功能分区将被注射 逆行示踪剂用于确定与 皮质和皮质下结构。

DESCRIPTION: (Adapted from the Applicant's Abstract.) The proposed studies will use a combined dichotic and free-field stimulation method to examine binaural response properties of single neurons, and determine how these response properties shape their sound location selectivity. Recording sites will be marked to determine if these neurons are anatomically organized with respect to binaural properties or spatial tuning. Radial penetrations through cortical columns will determine the homogeneity of response properties in a single column. The cortical surface will be mapped in two dimensions to determine whether aural types are anatomically segregated, and whether within each aural segregation there exists a finer level of functional organization. Results will be compared with similar studies of the inferior colliculus to study the transformation of response properties and functional organization from the midbrain to cortical level. Functional subdivisions of the cortical 60 kHz region will be injected with retrograde tracers to determine the specificity of connections with cortical and subcortical structures.