CELL CULTURE SURFACES FOR BONE RESEARCH

用于细胞培养的表面被用于骨研究的许多领域。 成骨细胞培养的研究目前被用于检测 导致骨骼生长、形态和功能的分子机制 矿化作用。对这些分子机制的理解给出了 洞察各种骨病的起源和治疗 包括儿童的生长障碍和POST的骨质疏松 更年期女性。最近，人们对此产生了相当大的兴趣。 机械应变对这些细胞生长的影响。 而一些用于细胞培养的柔性材料在循环条件下 已经提出了诱导应变，大多数的表面化学 柔性材料不太适合细胞培养，需要 在使用前进行涂层或其他表面改性。 本研究将重点研究三种材料的等离子体表面改性 成骨细胞培养领域当前感兴趣的材料 并确定表面处理对过程的影响。 成骨细胞培养和随后的矿化。

Surfaces for cell culture are used in many areas of bone research. The study of osteoblast cell culture is currently used to examine the molecular mechanisms leading to bone growth, morphology and mineralization. Understanding of these molecular mechanisms gives insight into the origins and treatment of various bone disorders including growth disorders in children and osteoporosis in post menopausal women. Recently considerable interest has arisen in the effects of mechanical strain on the growth of these cells. While some flexible materials for cell culture under cyclically induced strain have been proposed, the surface chemistry of most flexible materials is not well suited to cell culture and requires coating or other surface modification prior to use. This research will focus on the plasma surface modification of three materials of current interest in the area of osteoblast cell culture and determine the effects of surface treatment on the course osteoblast cell culture and subsequent mineralization.