AN IMPROVED WOUND DRESSING SUITABLE FOR BURN TREATMENT

本项目的目的是提供一种改进的伤口敷料 基于聚合物膜，该聚合物膜具有改变其 以适应伤口的特定条件。 这种膜将是透明的，细菌和液态水不能渗透， 并具有自粘附特性，这使得它可以容易地从 伤口表面。 一种新开发的聚合物组合物将被修改 以提供自调节的蒸汽渗透性或“智能” 行为 本发明提供了一种互穿聚合物网络（“IPN”）， 聚二甲基硅氧烷（“PDMS”）和聚四氟乙烯（“PTFE”）的混合物。 目前用作伤口敷料。 最终产品将具有 增加的湿气渗透性和流体储存能力， 大量渗出的伤口 同样的敷料会减少 渗出液时其透湿性降低，从而避免伤口 干燥 第一阶段项目将开始进行原型生产， 继续进行体外和体内试验，并得出结论， 第二阶段的结果和建议的解释。

The objective of this project is to provide an improved wound dressing based on a polymeric membrane which has the capability of changing its moisture vapor permeability to suit the particular conditions of the wound. The membrane will be transparent, impermeable to bacteria and liquid water, and possess self-cling properties which allow it to be easily removed from the wound surface. A newly developed polymer composition will be modified as to provide the self-adjusting vapor permeability or "intelligent" behavior. An interpenetrating polymer network ("IPN") of polydimethylsiloxane ("PDMS") and polytetrafluoroethylene ("PTFE") is currently used as a wound dressing. The resulting product will have increased moisture vapor permeability and fluid storage capacity when in the presence of heavily exuding wounds. The same dressing will decrease its vapor permeability when exudate decreases, thus avoiding wound desiccation. This Phase I project will begin with prototype production, continue with in vitro and in vivo testing, and conclude with interpretation of results and recommendations for Phase II.