ALUMINUM IN BRAIN DISEASES

铝与神经和衰老疾病有关， 包括老年痴呆症和透析痴呆症。 先前 痕量分析研究受到干扰， 污染，缺乏元素特异性，敏感性， 同位素信息 共振电离光谱（RIS）， 它利用激光原子计数技术，提供了潜在的 为了克服这些缺点，深入探讨 铝在神经生物学中的机械作用。 具体的目标是 1）发展简化的化学分离和雾化 研究铝的共振电离技术; 2）发展共振电离方案 3）论证铝的可行性 生物基质中的测定; 4）说明如何 技术可以应用于研究铝的作用， 神经系统疾病 在第二阶段， 第一阶段的方法将适用于以下具体问题： 神经生物学中的铝 也许可以评估 假设特定神经功能障碍是由 铝与亚细胞内特定化学位点的结合 结构. 这种能力可以导致开发一种手段， 早期诊断一种或多种这些疾病。 技术基础 将建立用于商业铝分析目前 超越了最先进的技术水平，RIS仪器将成为 传播给医学和分析界。

Aluminum has been implicated in neurological and aging disorders, including Alzheimer's disease and dialysis dementia. Previous trace analysis studies were subject to interferences and contamination, and lacked elemental specificity, sensitivity, and isotopic information. Resonance ionization spectroscopy (RIS), which utilizes laser atom counting techniques, offers the potential to overcome these disadvantages and to probe deeply the mechanistic role of aluminum in neurobiology. Specific aims are to: 1) develop simplified chemical separation and atomization techniques for aluminum; 2) develop resonance ionization schemes for aluminum; 3) demonstrate the feasibility of aluminum determinations in biological matrices; 4) illustrate how the technology can be applied to investigate the role of aluminum in neurological disorders. In Phase II the knowledge and methodology of Phase I will be applied to specific problems of aluminum in neurobiology. It may be possible to evaluate the hypothesis that specific neurological dysfunctions result from attachment of aluminum to specific chemical sites in subcellular structures. Such a capability could lead to developing a means of early diagnosis of one or more of these disorders. Technical bases will be established for commercial aluminum analyses currently beyond the state-of-the-art, and RIS instrumentation will be disseminated to the medical and analytical communities.