ACCELERATOR PRODUCTION OF EPITHERMAL NEUTRONS FOR BNCT

第二阶段计划的目标是建造和测试加速器 用于硼中子俘获治疗的基础中子照射设备 (BNCT)。在第一阶段，使用7Li(p，n)7Be产生的中子束 对BNCT的反应进行了研究。蒙特卡罗模拟的结果 慢化剂中的中子和光子输运的研究和脑等效物 利用体模设计了一个优化的中子辐照孔口。这些 计算表明，慢化加速器产生的中子 BEAM与目前最好的反应堆相竞争-- 关于剂量深度分布、剂量率和剂量的射束 组成。4 mA、2.5 MeV质子束流产生的中子通量 年，李灿为大脑中线的肿瘤提供治疗剂 不到一个小时。加速器中子源是基于一种新的 科学研究院目前正在开发的静电加速器技术 研究实验室。串列叶栅的显著特征 加速器(TCA)结构紧凑，功耗低，能够 以高达数百万的能量提供多毫安的质子电流 电子伏特。规模、资本和运营成本以及设施 此加速器的要求与在 研究实验室或医院。三氯乙烷和锂靶的设计 能够产生BNCT所需的高中子强度的是 在第一阶段完成第二阶段，加速器源将是 制造、表征并用于中子剂量学实验。它是 预计该系统将提供一种多功能的专用中子 BNCT研究的来源。

The goal of the Phase II program is to construct and test an accelerator based neutron irradiation facility for boron neutron capture therapy (BNCT). In Phase I, the use of neutron beams producted by the 7Li(p,n)7Be reaction for BNCT was investigated. The result of Monte-Carlo simulations of neutron and photon transport in moderators and a brain-equivalent phantom were used to design an optimized neutron irradiation port. These calculations demonstrated that a moderated accelerator-produced neutron beam is competitive with the best currently available reactor-produced beams with regard to dose-depth distribution, dose rate and dose composition. The neutron flux produced by a 4 mA, 2.5 MeV proton beam on Li can deliver a therapeutic dose to a tumor at the midline of the brain in less than one hour. The accelerator neutron source is based on a new electrostatic accelerator technology currently being developed at Science Research Laboratory. The salient features of the Tandem Cascade Accelerator (TCA) are compactness, low power consumption and the ability to deliver multi-milliampere proton currents at energies up to several million electron volts. The size, capital and operating costs, and facility requirements for this accelerator are compatible with installation in a research laboratory or hospital. The design of a TCA and lithium target capable of producing the high neutron intensities required for BNCT was completed in Phase I. In Phase II, the accelerator source will be fabricated, characterized and used in neutron dosimetry experiments. It is anticipated that this system will provide a versatile, dedicated neutron source for BNCT research.