MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

该提案要求提供资金购买变速器， 电子显微镜用于微血管研究。 主要用户 由7名调查员组成的小组，他们都从事 美国国立卫生研究院支持的研究活动，确定。 每个项目 主要用户需要电子显微镜， 研究工具或作为多学科研究方法的一部分 微循环 无法充分利用现有设备， 主要原因是：（1）调查人员众多 目前正在争夺显微镜时间，2）优先注册 合同工作，并由3）仪器不可用fillness 由于空间限制，在离线光谱分析期间，以及4） 机械故障，已经影响了我们 现有赠款承诺和延迟获得试验数据 新的建议采用电子显微镜。 拟议 仪器，按要求配备，将提供所需的 所有调查人员都可以访问，此外还提供直接 输入到数字化仪和计算机进行图像分析/存储， 加速数据采集和分析的能力 对于许多应用程序。 根据当前的需要， 在理论和实践中对显微镜的检验 JEOL JEM 1200 EX已被选中。 采购 电子显微镜的最后一步代表了一个为期5年的 旨在建立一个独立的，装备齐全的 微循环研究中的电子显微镜设备 院 该设施被认为是一个不可或缺的关键 研究所长期计划的一部分， 多学科研究的持续增长和生产力 团队致力于揭示 微循环行为的变化。

This proposal requests funds for the purchase of a transmission electron microscope for microvascular research. A major user group comprising seven investigators, all of whom are engaged in NIH supported research activities, is identified. Projects of each major user require electron microscopy either as a primary research tool or as part of a multidisciplinary approach to studies of the microcirculation. inadequate access to existing equipment, attributed primarily to 1) the large number of investigators currently vying for microscope time, 2) priority sign-up given contract work, and compounded by 3) instrument inavailabfility during off-line spectral analysis due to room limitations, and 4) mechanical failure, has compromised both our ability to meet existing grant commitments and delayed acquisition of pilot data for new proposals employing electron microscopy. The proposed instrument, equipped as requested, would afford the desired accessibility to all investigators and in addition provide direct input to digitizer and computer for image analysis/storage, capabilities which would accelerate data acquisition and alalysis for many applications. Based on current needs, and a thorough examination, in practice as well as theory, of the microscopes available, the JEOL JEM 1200EX has been selected. Procurement of an electron microscope represents the final step in a 5-year plan directed at establishing an independent, fully-equipped electron microscopy facility in the Microcirculation Research Institute. The facility is considered an integral an crucial component of the institute's long range plan to guarantee continued growth and productivity of a multidisciplinary research team striving to uncover the fundamental processes governing microcirculatory behavior in heatlh and disease.