MASS SPECTROMETER

德克萨斯健康大学的质谱学实验室 圣安东尼奥科学中心提供多用户支持 为卫生科学中心和西南地区服务 研究联盟。来自这些机构的调查人员， 参与生物医学研究的许多不同领域，利用 这个设施。目前，有两家惠普5982 四极质谱计和Finnigan-MAT 212磁体 扇形仪表。其中一个四极杆用于直接 插入探针EI样品和填充柱GC-MS分析。这个 其他四极杆已被改装成热喷雾高效液相色谱-质谱仪。这个 磁扇仪主要用于FAB和非FAB 常规毛细管气相色谱-质谱仪(EI或CI)。不太常见的是，DCI和高效液相色谱仪- 执行MS(皮带接口)。四极质谱计 是1975年制造的，现在已经过时了，在自然界中 他们的设计以及部件和服务的可用性。 惠普不再为这些设备提供服务合同， 而且许多部件已经不再生产了。新的弥撒 这个机构需要分光计：1)假设 目前正在对惠普公司进行的常规分析 四极杆；2)提供化学电离能力 负离子检测。第一个函数将保留 目前的状态，对于需要EI-GC-MS的项目是必不可少的 和直接插入探头分析。第二个函数将 提供一种具有卓越敏感性的技术和 选择性，这对促进在以下方面取得进一步进展至关重要 大量正在进行的调查。 这项提案的第二个方面是升级数据系统 在磁扇形仪器上。目前的安排是 数据存储，包括一个5mb的固定磁盘和5mb的可移动磁盘 墨盒，在光谱的数量上是受限的， 保存下来，使用起来既笨拙又费力 操纵。此外，Nova 4C计算机无法获得 数据以足够快的速度执行中分辨率毛细管 GC-MS联用 因此，一个新的四极质谱计是至关重要的 执行日常服务分析，并提供高度的 灵敏的NCI测量。购买了一个新的四极杆， 随着磁力部门数据系统的升级 工具，将显著提高成功的可能性 该机构的众多研究项目

The Mass Spectrometry Laboratory of the University of Texas Health Science Center at San Antonio functions as a multi-user support service for the Health Science Center and for the Southwest Research Consortium. Investigators from these institutions, involved in many different areas of biomedical research, utilize this facility. Currently, there are two Hewlett-Packard 5982 quadrupoles mass spectrometers and a Finnigan-MAT 212 magnetic sector instrument. One of the quadrupoles is used for direct insertion probe EI samples and packed column GC-MS analyses. The other quadrupole has been modified for thermospray HPLC-MS. The magnetic sector instrument is used primarily for FAB and non- routine capillary GC-MS (EI or CI). Less frequently, DCI and HPLC- MS (belt interface) are performed. quadrupole mass spectrometers were manufactured in 1975 and are now obsolete, both in the nature of their design and in the availability of parts and service. Hewlett-Packard no longer offers service contracts on these units, and many of the parts are not being made anymore. A new mass spectrometer is needed at this institution to: 1) assume the routine analyses currently being performed on the Hewlett-Packard quadrupole; 2) provide the capability for chemical ionization with negative ion detection. The first function will preserve the current status and is essential for projects requiring EI-GC-MS and direct insertion probe analyses. The second function will provide access to a technique of superior sensitivity and selectivity, which is critical to facilitate further progress in numerous ongoing investigations. A secondary aspect of this is proposal is upgrading the data system on the magnetic sector instrument. The current arrangement for data storage, which includes a 5 mb fixed disk and 5 mb removable cartridges, is restrictive in the number of spectra which can be preserved and is both unwieldy and laborious to use for file manipulation. Furthermore, the Nova 4C computer cannot acquire data at a fast enough rate to perform medium resolution capillary GC-MS. It is, therefore, essential that a new quadrupole mass spectrometer be obtained to perform daily service analyses and to provide highly sensitive NCI measurements. The purchase of a new quadrupole, along with upgrading of the data system on the magnetic sector instrument, will significantly enhance the probability for success of a multitude of research projects at this institution